{"id":"W2526698588","doi":"","title":"BRCA1 and BRCA2 Sequence Homopolymers Jeopardize Mutation Detection on the High-Throughput Pyrosequencing Platforms","year":2012,"lang":"en","type":"article","venue":"Current Oncology","topic":"bioluminescence and chemiluminescence research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"","keywords":"Pyrosequencing; Throughput; Mutation; Computational biology; Sequence (biology); Medicine; Genetics; Gene; Bioinformatics; Biology; Cancer research; Computer science; Operating system","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006518827,0.0006522071,0.0008926314,0.0008057334,0.0006752155,0.001790273,0.0009106975,0.001729675,0.001988734],"category_scores_gemma":[0.01506083,0.001303684,0.0005611253,0.0007387791,0.001015124,0.0009342177,0.0009535995,0.002489238,0.001435756],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003691922,"about_ca_system_score_gemma":0.0008810436,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004841648,"about_ca_topic_score_gemma":0.002115543,"domain_scores_codex":[0.9915389,0.003362229,0.0004172962,0.001186629,0.003117217,0.0003777869],"domain_scores_gemma":[0.9840321,0.01187112,0.001155891,0.001820462,0.0007859649,0.000334401],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004063726,0.0001065086,0.00487177,0.0002676465,0.0001240925,0.0002327481,0.000305508,0.001972649,0.9484826,0.003197057,0.001356719,0.03867624],"study_design_scores_gemma":[0.00002825022,0.0002143555,0.006779382,0.00007477217,0.0001082035,0.000911899,0.00007292288,0.01672121,0.9614666,0.003846087,0.00973217,0.00004431681],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.657036,0.004028955,0.3227646,0.002233048,0.0006680437,0.0001581893,0.0010104,0.004293744,0.007806949],"genre_scores_gemma":[0.7385651,0.001539645,0.2487317,0.003586844,0.0001498525,0.0002494043,0.001076253,0.001063371,0.005037875],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006518827,"threshold_uncertainty_score":0.03447527,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09771105554327773,"score_gpt":0.3777422397822376,"score_spread":0.2800311842389598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}