{"id":"W2526793520","doi":"10.1158/1078-0432.ccr-16-0453","title":"The MAPK Pathway Regulates Intrinsic Resistance to BET Inhibitors in Colorectal Cancer","year":2016,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute on Minority Health and Health Disparities; National Institute of Diabetes and Digestive and Kidney Diseases; Structural Genomics Consortium; Ontario Ministry of Economic Development and Innovation; National Institute of General Medical Sciences; Ontario Genomics Institute; Vanderbilt University; Wellcome Trust; National Cancer Institute; National Institutes of Health","keywords":"BET inhibitor; Bromodomain; Colorectal cancer; Cancer research; MAPK/ERK pathway; Cancer; Medicine; Epigenetics; Cell growth; Pharmacology; Signal transduction; Biology; Internal medicine; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001341868,0.0002695583,0.0002172161,0.0001900877,0.0001282797,0.0003033555,0.000106745,0.0001721989,0.001229189],"category_scores_gemma":[0.0001222052,0.0001166896,0.0001522534,0.0001269774,0.000130206,0.0001436877,0.0001214946,0.0004065667,0.000300378],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004539886,"about_ca_system_score_gemma":0.000231834,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002851417,"about_ca_topic_score_gemma":0.0006119681,"domain_scores_codex":[0.9999176,0.00001687299,0.000006056347,0.00001148446,0.00001918913,0.00002868122],"domain_scores_gemma":[0.9999501,0.000008407065,0.00001547121,0.000004093332,0.00000731605,0.00001472617],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005388974,0.0001496538,0.002720565,0.00006878718,0.0000134682,0.0001313526,0.00001525303,0.0003463806,0.9895857,0.0001764951,0.0001910868,0.006062423],"study_design_scores_gemma":[0.0001812607,0.002103482,0.06560358,0.00002085428,0.0000643883,0.002818483,0.00006611346,0.007555563,0.9154548,0.0002731232,0.005844578,0.00001382908],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951829,0.002445339,0.0005909743,0.0001113313,0.00001072854,0.00002719036,0.000195504,0.00004852507,0.001387578],"genre_scores_gemma":[0.9982005,0.0006902884,0.0003372146,0.00002317673,0.00000382158,0.00001245801,0.0001746859,0.000005017407,0.0005527392],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001229189,"threshold_uncertainty_score":0.004112065,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0648854301857114,"score_gpt":0.4284430275985762,"score_spread":0.3635575974128648,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}