{"id":"W2526805159","doi":"10.1007/978-1-4939-3768-4_8","title":"Spectral Confocal Imaging to Examine Upregulation of Nicotinic Receptor Subunits in α4-Yellow Fluorescent Protein Knock-In Mice","year":2016,"lang":"en","type":"book-chapter","venue":"Neuromethods","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Victoria","funders":"","keywords":"Gene knockin; Biology; Nicotinic agonist; Cell biology; Nicotinic acetylcholine receptor; Acetylcholine receptor; Embryonic stem cell; Receptor; Molecular biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009381239,0.0005554415,0.0007537912,0.0004258012,0.00002629801,0.00001576592,0.0004944475,0.0004419833,0.0002260272],"category_scores_gemma":[0.0004862518,0.0005452518,0.0002067768,0.0001568201,0.0001369489,0.000008415199,0.0003937038,0.0005037945,0.00004032209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001157185,"about_ca_system_score_gemma":0.0001888522,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002668982,"about_ca_topic_score_gemma":0.0001039718,"domain_scores_codex":[0.9966804,0.0003856599,0.001012503,0.001047273,0.0003438836,0.0005303263],"domain_scores_gemma":[0.9984438,0.0001155493,0.0004124249,0.0007117835,0.0001521673,0.0001642323],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002930801,0.0001113424,0.0009878408,0.0000795067,0.0000321302,0.000003346961,0.00005819242,0.00001504763,0.9670982,0.0004661089,0.0005084132,0.0303468],"study_design_scores_gemma":[0.002325528,0.0007983174,0.002196234,0.000788411,0.00003791992,0.00001912066,0.00001698168,0.0000475847,0.9141182,0.0002543557,0.07849409,0.0009032036],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8944598,0.001417496,0.003720607,0.001017446,0.001672752,0.005289561,0.0002333783,0.00007633177,0.09211264],"genre_scores_gemma":[0.6666697,0.0007874792,0.05178082,0.0005010686,0.002173892,0.0002355955,0.0004199275,0.0007174866,0.2767141],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2277901,"threshold_uncertainty_score":0.9996999,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01751171964055261,"score_gpt":0.2835714769117038,"score_spread":0.2660597572711512,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}