{"id":"W2527001605","doi":"10.1016/j.immuni.2016.08.010","title":"K + Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria","year":2016,"lang":"en","type":"article","venue":"Immunity","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":523,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Graduate School, Technische Universität München; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; National Health and Medical Research Council; Natural Sciences and Engineering Research Council of Canada; European Research Council; Elitenetzwerk Bayern; Tehran University of Medical Sciences and Health Services; Australian Research Council; Deutsches Zentrum für Infektionsforschung; European Synchrotron Radiation Facility; Deutsche Forschungsgemeinschaft; TUM Universitätsstiftung; Bayerisches Staatsministerium für Wissenschaft, Forschung und Kunst","keywords":"Inflammasome; Efflux; Biology; Mitochondrion; Cell biology; Biochemistry; Immunology; Inflammation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003042009,0.0003349453,0.0003432126,0.0001596887,0.0001958477,0.0004677111,0.0002204003,0.0004397605,0.00198998],"category_scores_gemma":[0.0002434163,0.0001557229,0.0003357955,0.0001412618,0.000296166,0.0007926592,0.0003710937,0.0006378869,0.000530412],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003025635,"about_ca_system_score_gemma":0.0001964102,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001062902,"about_ca_topic_score_gemma":0.0001890291,"domain_scores_codex":[0.9998782,0.0000280666,0.00001666152,0.00002322358,0.00002484804,0.00002903651],"domain_scores_gemma":[0.9998852,0.00002658944,0.00004144694,0.00001717082,0.00001317607,0.000016351],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009388766,0.00004178894,0.000140459,0.0001698305,0.00001436436,0.0001623479,0.00002838047,0.0001249188,0.9943002,0.0007103686,0.0001980924,0.003170265],"study_design_scores_gemma":[0.0002214461,0.0005627528,0.001989292,0.00001976912,0.00002637915,0.0006296588,0.00004693116,0.001169849,0.9906132,0.0006744397,0.004033622,0.00001268157],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9658033,0.01279941,0.01510921,0.001493935,0.0002047102,0.00009914938,0.0004803221,0.0001825031,0.003827525],"genre_scores_gemma":[0.991475,0.003133852,0.002865291,0.0001622695,0.000040897,0.00005561489,0.0001703353,0.00001815031,0.002078498],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00198998,"threshold_uncertainty_score":0.006657183,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005861632127103591,"score_gpt":0.2096041229239265,"score_spread":0.2037424907968229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}