{"id":"W2527003447","doi":"10.1159/000449381","title":"Pre-Implantation Genetic Screening Techniques: Implications for Clinical Prenatal Diagnosis","year":2016,"lang":"en","type":"review","venue":"Fetal Diagnosis and Therapy","topic":"Prenatal Screening and Diagnostics","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Ottawa Mental Health Centre","funders":"","keywords":"Aneuploidy; Genetic testing; Medicine; In vitro fertilisation; Advanced maternal age; Obstetrics; Embryo transfer; Gynecology; Blastocyst; Cell-free fetal DNA; Pregnancy; Embryo; Prenatal diagnosis; Biology; Fetus; Genetics; Internal medicine; Gene; Chromosome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004015239,0.0005839551,0.001761524,0.0002116402,0.0002200389,0.0000912843,0.0002578628,0.0006602877,0.00005522469],"category_scores_gemma":[0.0006430357,0.0003960153,0.0009200576,0.000202341,0.0001783719,0.000119962,0.0001047722,0.0003482916,0.00001880298],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004462545,"about_ca_system_score_gemma":0.0001540172,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003212644,"about_ca_topic_score_gemma":0.000004109615,"domain_scores_codex":[0.9971794,0.0001716976,0.001117422,0.0008653206,0.0002027694,0.0004633736],"domain_scores_gemma":[0.9940823,0.004272541,0.0005173731,0.0006160747,0.0001435119,0.0003681771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008935404,0.0003381761,0.01324388,0.00207803,0.0003968292,0.00000843722,0.00001081156,2.701683e-8,1.488009e-7,0.000128967,0.003309198,0.9803962],"study_design_scores_gemma":[0.001241982,0.001454915,0.0215211,0.02107616,0.0009526272,0.0001461345,0.000002004276,0.000002788697,0.00002176921,0.0002382615,0.9528431,0.0004991937],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002685848,0.9882712,0.004298609,0.000362795,0.0002273225,0.004304083,0.001892971,0.0002252739,0.0001491519],"genre_scores_gemma":[0.0002183061,0.9770904,0.008808088,0.000328199,0.001128836,0.01134781,0.0008613577,0.0001308724,0.00008614224],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.979897,"threshold_uncertainty_score":0.9998492,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1367938596611152,"score_gpt":0.4407103119029646,"score_spread":0.3039164522418494,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}