{"id":"W2527065525","doi":"10.1038/srep34237","title":"‘AND’ logic gates at work: Crystal structure of Rad53 bound to Dbf4 and Cdc7","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; McMaster University; University of Waterloo","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Canadian Light Source","keywords":"Phosphopeptide; Cell biology; Biology; Saccharomyces cerevisiae; Regulator; Computational biology; Kinase; Computer science; Genetics; Yeast; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001718827,0.0005111938,0.0008115743,0.0001832353,0.0009367976,0.00121542,0.00152414,0.0006895774,0.003865688],"category_scores_gemma":[0.0004203638,0.0004606379,0.0002605541,0.0002733706,0.0006109538,0.0007546458,0.0003661681,0.001568736,0.0003425782],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001301148,"about_ca_system_score_gemma":0.001160086,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008157071,"about_ca_topic_score_gemma":0.006380915,"domain_scores_codex":[0.9998536,0.00001676452,0.000003701464,0.00001986635,0.0000573021,0.00004874569],"domain_scores_gemma":[0.9998817,0.00004533183,0.00001456509,0.000007196881,0.00002083931,0.00003026956],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005307158,0.002492958,0.01984146,0.002331501,0.001020315,0.0113439,0.003182592,0.1004651,0.6363169,0.06996569,0.06627455,0.08145789],"study_design_scores_gemma":[0.002611537,0.001386006,0.02862754,0.0002795465,0.0004943206,0.00249784,0.002648896,0.4807275,0.3525508,0.01710128,0.110662,0.0004127613],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9836775,0.001849154,0.002431665,0.0009610431,0.0001850936,0.00002252419,0.0003584825,0.0003824271,0.01013219],"genre_scores_gemma":[0.9877493,0.001417276,0.004018553,0.0003163997,0.00003910394,0.00003858193,0.001945934,0.00008433418,0.004390572],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008157071,"threshold_uncertainty_score":0.0162192,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007346185030913275,"score_gpt":0.2248192702657723,"score_spread":0.217473085234859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}