{"id":"W2527216906","doi":"10.1038/srep33916","title":"HB-GAM (pleiotrophin) reverses inhibition of neural regeneration by the CNS extracellular matrix","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Proteoglycans and glycosaminoglycans research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women and Children’s Health Research Institute","funders":"Sigrid Juséliuksen Säätiö; Tekes","keywords":"Pleiotrophin; Chondroitin sulfate proteoglycan; Neurite; Regeneration (biology); Cell biology; Central nervous system; Protein tyrosine phosphatase; Chondroitin sulfate; Neuroscience; CREB; Biology; Glial scar; Chemistry; Extracellular matrix; Proteoglycan; In vitro; Growth factor; Receptor; Biochemistry; Signal transduction; Glycosaminoglycan; Astrocyte; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000762823,0.0002527167,0.0001553052,0.0001780157,0.00007631672,0.0001335403,0.0001370592,0.0001710671,0.001068938],"category_scores_gemma":[0.00005950866,0.00006279643,0.00009823982,0.00007237239,0.0002113591,0.00009913088,0.0001148181,0.0004554142,0.0001931999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009682828,"about_ca_system_score_gemma":0.0001842766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004153672,"about_ca_topic_score_gemma":0.0009111384,"domain_scores_codex":[0.9999559,0.000009602215,0.00000266114,0.000004100818,0.00001504027,0.00001278366],"domain_scores_gemma":[0.9999578,0.000007034315,0.000009712031,0.000002679041,0.000003598181,0.00001930395],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001971644,0.00007278605,0.00008377072,0.00003797466,0.00000499746,0.00005968109,0.000006996146,0.00005679211,0.9953744,0.00007999597,0.00005242818,0.003972982],"study_design_scores_gemma":[0.00006046421,0.001194432,0.002388263,0.000005537615,0.00001380526,0.0002681225,0.00001957622,0.0004698066,0.9939153,0.00004581456,0.00161591,0.000003055404],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958105,0.001310288,0.001158523,0.0001041955,0.00002784823,0.00002372567,0.00008022696,0.0000836159,0.001401052],"genre_scores_gemma":[0.9937693,0.001572699,0.001859592,0.00005049306,0.0000171719,0.000022577,0.0001591674,0.00001570321,0.002533147],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001068938,"threshold_uncertainty_score":0.003575981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01196991983854946,"score_gpt":0.2614628696823303,"score_spread":0.2494929498437809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}