{"id":"W2527298399","doi":"10.1101/076794","title":"Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility","year":2016,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; Centre for Global Health Research","funders":"","keywords":"Mendelian randomization; Menarche; Biology; Heritability; Population; Prostate cancer; Genetics; Physiology; Endocrinology; Genotype; Oncology; Demography; Gene; Cancer; Medicine; Genetic variants","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008230196,0.0006160992,0.0007579551,0.0002133503,0.0001674209,0.00009912724,0.0005679165,0.0007112225,0.00003671611],"category_scores_gemma":[0.0002960483,0.0005440213,0.0003189914,0.0001109269,0.0001886484,0.000008592796,0.001794556,0.0003147762,0.000008573738],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002379728,"about_ca_system_score_gemma":0.0003382748,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008011171,"about_ca_topic_score_gemma":0.00003463468,"domain_scores_codex":[0.9965127,0.0002039591,0.0007127762,0.001516491,0.0003930599,0.0006609824],"domain_scores_gemma":[0.9973193,0.0001157505,0.0007769227,0.001229834,0.0002711996,0.000286926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006350519,0.0001013902,0.03138071,0.001046746,0.0005676878,0.00000875777,0.00001516282,0.00007355641,0.9666175,0.000008540019,0.00008592256,0.00003047148],"study_design_scores_gemma":[0.0007698669,0.0001753254,0.295364,0.000348208,0.0002039704,5.49286e-8,0.000003130607,0.00003192793,0.7023922,0.000006487508,0.0002507774,0.0004540657],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934348,0.002708836,0.00151633,0.00007449258,0.0005478718,0.001409736,0.000270617,0.000028784,0.000008558899],"genre_scores_gemma":[0.9974173,0.000822617,0.0008461743,0.00008966315,0.000309312,0.0003416606,0.000002405699,0.000118956,0.00005185371],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2642254,"threshold_uncertainty_score":0.9997011,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03228565572964071,"score_gpt":0.2978485590993267,"score_spread":0.265562903369686,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}