{"id":"W2527322529","doi":"10.1021/acs.jmedchem.6b01200","title":"A Cyclic Tetrapeptide (“Cyclodal”) and Its Mirror-Image Isomer Are Both High-Affinity μ Opioid Receptor Antagonists","year":2016,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; William Osler Health System; Montreal Clinical Research Institute","funders":"National Institute on Drug Abuse; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Tetrapeptide; Chemistry; Stereochemistry; Receptor; Opioid; Opioid receptor; Pharmacology; Biochemistry; Peptide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005658328,0.0002545942,0.0001493315,0.0001065605,0.00009227592,0.0001966801,0.0002377266,0.0002207107,0.001958944],"category_scores_gemma":[0.0001132505,0.0001201503,0.0001486314,0.0001009869,0.0002113027,0.0001621854,0.0001583421,0.0003858842,0.0003575703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002127705,"about_ca_system_score_gemma":0.0001715545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003304617,"about_ca_topic_score_gemma":0.0004588492,"domain_scores_codex":[0.9999306,0.000009337151,0.000005525656,0.00001828397,0.00001678995,0.00001945515],"domain_scores_gemma":[0.999927,0.00001125057,0.00002714488,0.000006826492,0.000007519317,0.00002024554],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002985684,0.0000476745,0.0001990264,0.00008823242,0.000008887522,0.0001240221,0.00001604896,0.0002084628,0.9917629,0.000394316,0.0001903461,0.006661689],"study_design_scores_gemma":[0.0001249949,0.002316869,0.00267056,0.00001204168,0.00002543219,0.00104676,0.00003169778,0.0009764567,0.9823512,0.00007476668,0.01034999,0.00001934331],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899282,0.001681945,0.00319379,0.0001599656,0.00006992514,0.00007380933,0.0003838898,0.0000627543,0.004445651],"genre_scores_gemma":[0.9928357,0.0008849899,0.003368005,0.0001688347,0.00002905514,0.00005697244,0.0004090441,0.00001227949,0.002235101],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001958944,"threshold_uncertainty_score":0.006553292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01966154571112531,"score_gpt":0.2552249332829543,"score_spread":0.2355633875718289,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}