{"id":"W2527639882","doi":"10.1097/tp.0000000000001492","title":"Immunosuppressive Treatment Alters Secretion of Ileal Antimicrobial Peptides and Gut Microbiota, and Favors Subsequent Colonization by Uropathogenic Escherichia coli","year":2016,"lang":"en","type":"article","venue":"Transplantation","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":135,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; Michael Smith Health Research BC; University of Alberta; Natural Sciences and Engineering Research Council of Canada","funders":"","keywords":"Microbiology; Biology; Gut flora; Bacteroidetes; Feces; Escherichia coli; Firmicutes; Antimicrobial; Bacteria; Immunology; 16S ribosomal RNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001186982,0.0003465393,0.0003078182,0.0002504727,0.0001315502,0.0002807859,0.0001333035,0.000220112,0.001205289],"category_scores_gemma":[0.0001221321,0.00007211797,0.0002457506,0.0001665049,0.0002299435,0.0001239351,0.0001005754,0.0003830845,0.000172857],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001508312,"about_ca_system_score_gemma":0.0001812269,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001948256,"about_ca_topic_score_gemma":0.0003333576,"domain_scores_codex":[0.9998028,0.00003629315,0.00001859537,0.0000326774,0.00005486063,0.00005489323],"domain_scores_gemma":[0.9997928,0.0000169916,0.00009151892,0.00001679323,0.00001874124,0.0000632354],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006385872,0.000113116,0.002769511,0.00006934979,0.00001651024,0.00008253512,0.00001110772,0.00003346319,0.9927148,0.00001900935,0.00004788228,0.003484135],"study_design_scores_gemma":[0.00006292958,0.004805662,0.1407213,0.00003865505,0.0001228296,0.0008289308,0.0001156394,0.0004639715,0.8496627,0.00003999293,0.003125863,0.00001155331],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971943,0.001661313,0.000300333,0.00005150533,0.0000243158,0.00001221082,0.0001329226,0.00002935749,0.0005936502],"genre_scores_gemma":[0.9981329,0.0007091184,0.0003432647,0.00006951536,0.00002354402,0.00001919299,0.0001766465,0.000005036309,0.0005208454],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001205289,"threshold_uncertainty_score":0.004032135,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005455411724694354,"score_gpt":0.2205699862112116,"score_spread":0.2151145744865172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}