{"id":"W2527639882","doi":"10.1097/tp.0000000000001492","title":"Immunosuppressive Treatment Alters Secretion of Ileal Antimicrobial Peptides and Gut Microbiota, and Favors Subsequent Colonization by Uropathogenic Escherichia coli","year":2016,"lang":"en","type":"article","venue":"Transplantation","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":135,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; Michael Smith Health Research BC; University of Alberta; Natural Sciences and Engineering Research Council of Canada","funders":"","keywords":"Microbiology; Biology; Gut flora; Bacteroidetes; Feces; Escherichia coli; Firmicutes; Antimicrobial; Bacteria; Immunology; 16S ribosomal RNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005968848,0.0001365664,0.00013414,0.00003427888,0.00007260819,0.00001197421,0.00003779178,0.0001096003,0.000005583071],"category_scores_gemma":[0.000003585611,0.0001086249,0.00003203083,0.0000372882,0.0001134354,0.00001033325,0.000007997342,0.00002371871,0.000001446122],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002682858,"about_ca_system_score_gemma":0.00005096732,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001168525,"about_ca_topic_score_gemma":0.00008758933,"domain_scores_codex":[0.9992833,0.00007461706,0.0002009101,0.000250218,0.0000405336,0.0001503824],"domain_scores_gemma":[0.9996867,0.00001267106,0.0001123098,0.00009224769,0.00004731103,0.00004877886],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003627461,0.00004456683,0.004085751,0.00009311884,0.00003467751,0.000001273046,0.000400879,0.000002996712,0.9939593,0.0000143042,0.0001279238,0.000872442],"study_design_scores_gemma":[0.00200278,0.0005403739,0.06849653,0.00007175718,0.00007854697,0.0000410495,0.00003882283,0.000008248129,0.9281558,0.00000385648,0.0004186734,0.000143555],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966168,0.0004820304,0.001878098,0.0001443169,0.00005932033,0.0002952108,0.0005020218,0.000007849379,0.00001430684],"genre_scores_gemma":[0.9901423,0.008463211,0.0003509967,0.00006041852,0.00002602559,0.000008987534,0.0008381779,0.00001511785,0.00009478781],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06580351,"threshold_uncertainty_score":0.4429594,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005455411724694354,"score_gpt":0.2205699862112116,"score_spread":0.2151145744865172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}