{"id":"W2527662309","doi":"10.1186/s13059-016-1069-y","title":"DNA replication stress: a source of APOBEC3B expression in breast cancer","year":2016,"lang":"en","type":"letter","venue":"Genome biology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; Cancer Research Society","keywords":"APOBEC; Biology; Human genetics; Oncogene; Genetics; Cytidine; Cytidine deaminase; Mutation; DNA replication; DNA; Computational biology; Gene; Cancer research; Cell cycle; Enzyme; Genome; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001308201,0.0002656281,0.0003697764,0.0001261587,0.00002776288,0.000007167272,0.0004110628,0.001057859,0.0001128767],"category_scores_gemma":[0.00004462893,0.0002229125,0.0001208324,0.00006845717,0.0001463407,0.00000163299,0.0002580651,0.0002619629,0.00001094931],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007523649,"about_ca_system_score_gemma":0.0002039952,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002386655,"about_ca_topic_score_gemma":0.00007910946,"domain_scores_codex":[0.9982473,0.00009226416,0.0004097731,0.0007837088,0.00007365194,0.0003933552],"domain_scores_gemma":[0.9984702,0.0000423409,0.0003546734,0.0009815188,0.0001080912,0.00004313425],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007887158,0.00002266925,0.004619962,0.00008128411,0.00004329005,0.000003780601,0.00002430332,0.00001427498,0.8641003,0.000006027904,0.1258837,0.00512155],"study_design_scores_gemma":[0.0004544618,0.00009945386,0.002786362,0.00009283384,0.00001885428,0.00001139715,0.000006449696,0.00000132364,0.05402756,0.000100403,0.9421054,0.0002955218],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"commentary","genre_scores_codex":[0.4749559,0.02780337,0.003337147,0.4688403,0.002289618,0.002062981,0.01879248,0.00005966525,0.001858525],"genre_scores_gemma":[0.4379852,0.04387635,0.0008413787,0.4487911,0.03948073,0.001406518,0.01956641,0.0005043719,0.007547945],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.8162217,"threshold_uncertainty_score":0.9090106,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008513891187575385,"score_gpt":0.2480958053162564,"score_spread":0.239581914128681,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}