{"id":"W2527703292","doi":"10.1182/blood.v126.23.1227.1227","title":"Reversion to an Embryonic Alternative Splicing Program Enhances Leukemia Stem Cell Self-Renewal","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Princess Margaret Cancer Centre; Canada's Michael Smith Genome Sciences Centre; BC Cancer Agency","funders":"","keywords":"Biology; Embryonic stem cell; Stem cell; Reprogramming; Progenitor cell; Gene knockdown; Small hairpin RNA; Cancer research; Cell biology; Molecular biology; Cell; Cell culture; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001354592,0.0001868296,0.0002088216,0.0001476745,0.00009276522,0.000281094,0.0001517275,0.0001514863,0.001757145],"category_scores_gemma":[0.00008729647,0.00007115946,0.0001955376,0.0001268397,0.0001763978,0.0001547979,0.0001891068,0.0004440664,0.0003076891],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002673518,"about_ca_system_score_gemma":0.000161923,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003220617,"about_ca_topic_score_gemma":0.0003749988,"domain_scores_codex":[0.9998537,0.00001409204,0.00001438262,0.00004022052,0.00005321807,0.00002440673],"domain_scores_gemma":[0.9999002,0.00001669889,0.00003243486,0.00001454159,0.00001647576,0.00001963164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002423747,0.000006851545,0.000165777,0.00002750604,0.000002801218,0.00001350628,0.00000651844,0.00004319874,0.9985577,0.0001011863,0.00002972652,0.001020807],"study_design_scores_gemma":[0.000008455826,0.0001226027,0.003370814,0.00000591976,0.00001797696,0.00008380398,0.00001562592,0.001342989,0.9907048,0.0001042309,0.004219231,0.000003423893],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9841537,0.001606901,0.01053904,0.0001233065,0.00003977477,0.00003438348,0.001027303,0.0003850527,0.002090518],"genre_scores_gemma":[0.9944834,0.0004639095,0.002220776,0.00007506552,0.000008184606,0.00002504019,0.0007649845,0.00004100554,0.001917726],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001757145,"threshold_uncertainty_score":0.00587821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0168836633418151,"score_gpt":0.286479964301716,"score_spread":0.2695963009599008,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}