{"id":"W2527713631","doi":"10.1002/hon.2351","title":"Proteasome inhibitors in AL amyloidosis: focus on mechanism of action and clinical activity","year":2016,"lang":"en","type":"review","venue":"Hematological Oncology","topic":"Amyloidosis: Diagnosis, Treatment, Outcomes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ministry of Health, British Columbia; Mental Health Association of Westchester County","keywords":"Ixazomib; Bortezomib; Carfilzomib; Amyloidosis; Multiple myeloma; Proteasome inhibitor; Medicine; Proteasome; AL amyloidosis; Pharmacology; Oncology; Cancer research; Internal medicine; Immunoglobulin light chain; Immunology; Chemistry; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006463206,0.0006122846,0.001152626,0.002211055,0.0002266478,0.0008829983,0.000601172,0.0008324824,0.002491612],"category_scores_gemma":[0.0009905527,0.0002143318,0.0006443682,0.001869319,0.0004408354,0.00124885,0.0005298945,0.001946447,0.0009949569],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005422873,"about_ca_system_score_gemma":0.0009142064,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006358393,"about_ca_topic_score_gemma":0.001247212,"domain_scores_codex":[0.9997723,0.00003910879,0.00004970971,0.00004280319,0.00007476701,0.00002141069],"domain_scores_gemma":[0.9995071,0.0002724287,0.00006472111,0.00001248977,0.0001106679,0.00003261914],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000142219,0.00009237958,0.0003700678,0.02003191,0.0001210664,0.0003281739,0.00007686129,0.0004231194,0.001715253,0.002571031,0.02241614,0.9517117],"study_design_scores_gemma":[0.00003617513,0.0002531564,0.001575292,0.00910725,0.00026049,0.003876711,0.00007759374,0.0001466273,0.000822296,0.002366878,0.9814496,0.00002793473],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001100651,0.9990724,0.00005670349,0.0002013879,0.0000908354,0.000001840397,0.00001030037,0.000004163464,0.000452331],"genre_scores_gemma":[0.0007506825,0.9986039,0.0001098648,0.0001550907,0.0001429538,0.000002955837,0.00001853008,0.000001123494,0.0002149569],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002491612,"threshold_uncertainty_score":0.008335292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07908604674415905,"score_gpt":0.4205617516177201,"score_spread":0.341475704873561,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}