{"id":"W2527847483","doi":"10.1787/5jlsvvxn1zjc-en","title":"Adverse Outcome Pathway on Alkylation of DNA in Male Pre-Meiotic Germ Cells Leading to Heritable Mutations","year":2016,"lang":"en","type":"paratext","venue":"OECD series on adverse outcome pathways","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University; Health Canada","funders":"","keywords":"Meiosis; Genetics; Biology; Germ; Germline; Adverse Outcome Pathway; Germ cell; Alkylation; Cell biology; Gene; Computational biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002714344,0.0009030824,0.0004531673,0.001526932,0.0009792144,0.001529416,0.001222797,0.002936406,0.0251203],"category_scores_gemma":[0.001951736,0.0002725041,0.0009301401,0.0007298086,0.001572035,0.001287725,0.00294036,0.00172138,0.008129814],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001441997,"about_ca_system_score_gemma":0.003251734,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002645185,"about_ca_topic_score_gemma":0.0053818,"domain_scores_codex":[0.9971519,0.0004780772,0.0001409741,0.0002593778,0.001603668,0.0003660284],"domain_scores_gemma":[0.9986231,0.0003475121,0.0002201023,0.0001691013,0.0004768127,0.0001633834],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0006494226,0.0005188589,0.002874383,0.004369064,0.00007745572,0.003609319,0.0006862488,0.003420901,0.2123091,0.1961124,0.2002422,0.3751306],"study_design_scores_gemma":[0.00005140088,0.0007535311,0.003941044,0.0007138324,0.0000441324,0.001591908,0.0001997971,0.0003669606,0.158332,0.0206681,0.813283,0.00005439494],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"other","genre_gemma":"methods","genre_scores_codex":[0.0319937,0.01653365,0.06218681,0.01742662,0.003996653,0.00129136,0.006014023,0.001962732,0.8585944],"genre_scores_gemma":[0.2253095,0.06950218,0.04352269,0.01629123,0.001367335,0.001355154,0.01234658,0.0005417718,0.6297635],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.0251203,"threshold_uncertainty_score":0.08403581,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01754271309100722,"score_gpt":0.2978753135767306,"score_spread":0.2803326004857233,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}