{"id":"W2527847483","doi":"10.1787/5jlsvvxn1zjc-en","title":"Adverse Outcome Pathway on Alkylation of DNA in Male Pre-Meiotic Germ Cells Leading to Heritable Mutations","year":2016,"lang":"en","type":"paratext","venue":"OECD series on adverse outcome pathways","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University; Health Canada","funders":"","keywords":"Meiosis; Genetics; Biology; Germ; Germline; Adverse Outcome Pathway; Germ cell; Alkylation; Cell biology; Gene; Computational biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002766023,0.00069353,0.0008398775,0.0004172509,0.0001053105,0.00002076428,0.0004157289,0.0005938372,0.0008982698],"category_scores_gemma":[0.0001152239,0.0006654707,0.0003607221,0.0001876969,0.00008725008,0.00002152318,0.0001865447,0.0003400587,0.002802226],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001792175,"about_ca_system_score_gemma":0.0001507443,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002988105,"about_ca_topic_score_gemma":0.0001326065,"domain_scores_codex":[0.99688,0.00009396019,0.00104545,0.0009016735,0.0003884686,0.0006904764],"domain_scores_gemma":[0.9982601,0.00007257817,0.0003604777,0.0009756647,0.000101935,0.0002291965],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005485371,0.0002771224,0.002466693,0.0007917766,0.0001402674,0.00005298932,0.0005368365,0.07308666,0.9144002,0.0002736507,0.006245493,0.00117982],"study_design_scores_gemma":[0.001981815,0.00145172,0.003100255,0.0005552939,0.00006898087,0.00001894413,0.0004964091,0.00006427464,0.7637419,0.00001940406,0.2269591,0.00154189],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8811455,0.0003489286,0.004609603,0.0002528925,0.005110674,0.002305407,0.002770164,0.00007966561,0.1033772],"genre_scores_gemma":[0.8179171,0.000142484,0.001048326,0.0002790208,0.0003295126,0.0001365408,0.0007142244,0.0001645451,0.1792682],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2207136,"threshold_uncertainty_score":0.9995797,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01754271309100722,"score_gpt":0.2978753135767306,"score_spread":0.2803326004857233,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}