{"id":"W2527880638","doi":"10.1016/j.cell.2016.09.032","title":"Empowering Older Antibiotics","year":2016,"lang":"en","type":"article","venue":"Cell","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"","keywords":"Periplasmic space; Biology; Antibiotics; Ceftazidime; Cephalosporin; Microbiology; Cephalosporin Antibiotic; Penicillin; Ceftazidime/avibactam; Beta-Lactamase Inhibitors; Penicillin binding proteins; Avibactam; Bacteria; Biochemistry; Escherichia coli; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005185891,0.00008856242,0.00006868836,0.00001297094,0.00002830985,0.00001224444,0.0001339077,0.00008819947,0.00009213299],"category_scores_gemma":[0.0000226105,0.00006199872,0.00004336789,0.00002577582,0.00005918604,0.000001961113,0.00006809997,0.00002202856,0.000123789],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007215452,"about_ca_system_score_gemma":0.00002115723,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":8.811488e-7,"about_ca_topic_score_gemma":0.000001719829,"domain_scores_codex":[0.9994345,0.0000131453,0.0001025336,0.000213937,0.00005565375,0.0001801798],"domain_scores_gemma":[0.9995691,0.000006409964,0.00003838421,0.0003107677,0.00002758631,0.00004781698],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000110936,0.0000193248,0.01246484,0.00001018424,0.000005562671,0.000002948971,0.00000746734,2.728377e-7,0.9837262,0.00001850853,0.003127185,0.0006064206],"study_design_scores_gemma":[0.0002715807,0.00004008363,0.02425759,0.00002107899,0.000003882206,0.000003244377,0.00001535186,7.612124e-7,0.9254279,0.00001712785,0.04982079,0.0001206394],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837242,0.0001533277,0.00539281,0.00007546223,0.0002601846,0.00005684502,0.000005988545,0.00001343451,0.01031771],"genre_scores_gemma":[0.9886255,0.0001550581,0.001006613,0.00008673383,0.0001751048,1.292922e-7,0.000006887045,0.00001963299,0.009924397],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05829833,"threshold_uncertainty_score":0.2528234,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006485122654846979,"score_gpt":0.2470530507548411,"score_spread":0.2405679280999941,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}