{"id":"W2527882322","doi":"10.1038/ncomms12832","title":"Dimerization deficiency of enigmatic retinitis pigmentosa-linked rhodopsin mutants","year":2016,"lang":"en","type":"article","venue":"Nature Communications","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Eye Institute; University of Toronto; Arnold and Mabel Beckman Initiative for Macular Research; National Institutes of Health; Qatar National Research Fund; Brandeis University; Austrian Science Fund; National Institute of General Medical Sciences; Velux Stiftung; Weill Cornell Medical College; Fonds National de la Recherche Luxembourg; Research to Prevent Blindness","keywords":"Rhodopsin; Retinitis pigmentosa; Phospholipid scramblase; Transducin; Biology; Cell biology; Mutant; Visual phototransduction; Mutation; Chemistry; Retinal; Biochemistry; Phospholipid; Membrane; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001409793,0.00008490359,0.00008784972,0.00004604067,0.00009577761,0.000007458581,0.0005131482,0.000177341,0.00002606775],"category_scores_gemma":[0.000401601,0.00006455011,0.00004645946,0.0001570778,0.0001382644,0.000005462595,0.00018014,0.00009240983,0.00001036587],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009009296,"about_ca_system_score_gemma":0.0000642842,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003079549,"about_ca_topic_score_gemma":0.00003696656,"domain_scores_codex":[0.9993285,0.00009268682,0.0002152574,0.000137305,0.0001127664,0.0001134761],"domain_scores_gemma":[0.9988509,0.00005381987,0.0001216295,0.0008138464,0.0001275983,0.00003213905],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002755862,0.0001142132,0.01990483,0.00001369495,0.00002404705,1.689179e-7,0.00009391714,8.754817e-7,0.9643038,0.005165936,0.00163251,0.008718457],"study_design_scores_gemma":[0.00315679,0.0005193211,0.3914334,0.0004084254,0.0001276338,0.00002725352,0.0005635018,0.0001106295,0.426021,0.00383565,0.1726812,0.001115219],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9527019,0.008326177,0.005715031,0.004146403,0.0002005571,0.0004158086,0.00005361996,0.0000367137,0.02840374],"genre_scores_gemma":[0.9917138,0.002556541,0.00505926,0.0001184048,0.0000126283,0.00001848093,0.0001751235,0.00001080576,0.0003349374],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5382828,"threshold_uncertainty_score":0.2632277,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0133712442693611,"score_gpt":0.2802459399359848,"score_spread":0.2668746956666237,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}