{"id":"W2527882322","doi":"10.1038/ncomms12832","title":"Dimerization deficiency of enigmatic retinitis pigmentosa-linked rhodopsin mutants","year":2016,"lang":"en","type":"article","venue":"Nature Communications","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Eye Institute; University of Toronto; Arnold and Mabel Beckman Initiative for Macular Research; National Institutes of Health; Qatar National Research Fund; Brandeis University; Austrian Science Fund; National Institute of General Medical Sciences; Velux Stiftung; Weill Cornell Medical College; Fonds National de la Recherche Luxembourg; Research to Prevent Blindness","keywords":"Rhodopsin; Retinitis pigmentosa; Phospholipid scramblase; Transducin; Biology; Cell biology; Mutant; Visual phototransduction; Mutation; Chemistry; Retinal; Biochemistry; Phospholipid; Membrane; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001174039,0.0004165993,0.000159145,0.0003076061,0.0001933984,0.0002064607,0.000180824,0.0003109403,0.00112479],"category_scores_gemma":[0.000153724,0.000180823,0.0002786094,0.000112014,0.0001833362,0.0001118363,0.0002737512,0.0003566091,0.0005366665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000237648,"about_ca_system_score_gemma":0.0001964767,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009784615,"about_ca_topic_score_gemma":0.0008935644,"domain_scores_codex":[0.999773,0.00005743665,0.00003292803,0.00005081976,0.00005437236,0.00003155197],"domain_scores_gemma":[0.9998415,0.00002129701,0.0000553449,0.00001581603,0.00001168034,0.00005437458],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000283757,0.00001062093,0.0001609759,0.000007989213,0.000004218383,0.000115979,0.00001472419,0.00003882847,0.9991783,0.00004547368,0.00001869071,0.0003758494],"study_design_scores_gemma":[0.00002413065,0.0001753192,0.01196338,0.000008881158,0.00002786008,0.002628128,0.0001033912,0.001956916,0.9811167,0.00009697009,0.001883882,0.00001451996],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960091,0.0002871578,0.002323276,0.00006442834,0.00001615954,0.00001861012,0.0003048776,0.00006996065,0.0009063806],"genre_scores_gemma":[0.9972944,0.0001344047,0.0009934601,0.00002869004,0.000003409508,0.000009800827,0.0002343832,0.00002530796,0.001276104],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00112479,"threshold_uncertainty_score":0.003762841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0133712442693611,"score_gpt":0.2802459399359848,"score_spread":0.2668746956666237,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}