{"id":"W2528087320","doi":"10.1093/infdis/jiw467","title":"Induction of an Immune-Protective T-Cell Repertoire With Diverse Genetic Coverage by a Novel Viral-Vectored Tuberculosis Vaccine in Humans","year":2016,"lang":"en","type":"article","venue":"The Journal of Infectious Diseases","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; McMaster University Medical Centre","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; American Educational Research Association","keywords":"Epitope; Tuberculosis; Mycobacterium tuberculosis; Virology; Immunology; Human leukocyte antigen; Antigen; Immune system; Tuberculosis vaccines; Biology; Cytotoxic T cell; Latent tuberculosis; T cell; CD8; BCG vaccine; Medicine; Vaccination; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005438676,0.0002166892,0.0002015325,0.000136886,0.0001177254,0.0002793864,0.0001565442,0.0004391146,0.001211076],"category_scores_gemma":[0.000302941,0.0001130247,0.0001221855,0.00005260274,0.0003066898,0.0002744905,0.0001320075,0.0004472709,0.0002688394],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001762907,"about_ca_system_score_gemma":0.0001394558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007345539,"about_ca_topic_score_gemma":0.00004588985,"domain_scores_codex":[0.9998636,0.00004814309,0.000007074798,0.00003655798,0.00001916105,0.0000254004],"domain_scores_gemma":[0.9999207,0.00002177064,0.0000145265,0.00001995699,0.000006668123,0.00001634852],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001043159,0.0008817796,0.007230561,0.0001634347,0.00003529538,0.0004965268,0.0001550488,0.0005098606,0.9287555,0.001775328,0.0007881835,0.05816535],"study_design_scores_gemma":[0.002629757,0.07600002,0.1091647,0.0004035167,0.0002994595,0.03413109,0.0005315338,0.01164416,0.7007431,0.008150418,0.0562331,0.00006919954],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985918,0.001956317,0.008812672,0.0004126206,0.00005681663,0.00008474554,0.00009661304,0.0001570972,0.002505063],"genre_scores_gemma":[0.9951197,0.0005733432,0.003214777,0.0002109973,0.00002051056,0.00004915677,0.0001078567,0.0000096276,0.0006940849],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001211076,"threshold_uncertainty_score":0.004051447,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00973793788486911,"score_gpt":0.2619927374636992,"score_spread":0.2522547995788301,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}