{"id":"W2528150422","doi":"10.1371/journal.pgen.1006350","title":"Metal Chelation as a Powerful Strategy to Probe Cellular Circuitry Governing Fungal Drug Resistance and Morphogenesis","year":2016,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; Ministry of Trade, Industry and Energy; Canada Research Chairs","keywords":"Caspofungin; Echinocandin; Echinocandins; Biology; Candida albicans; Anidulafungin; Antifungal drug; Drug resistance; Ponatinib; Virulence; Allosteric regulation; Fungal protein; Microbiology; Mutant; Gene; Dasatinib; Cell biology; Signal transduction; Biochemistry; Tyrosine kinase; Enzyme; Amphotericin B","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002147067,0.0003229496,0.0002737347,0.0003287798,0.0002682815,0.0004218712,0.0003412082,0.0004791561,0.001306756],"category_scores_gemma":[0.0001922099,0.0002188342,0.0002322473,0.0002367758,0.0003531748,0.0003063836,0.0003284173,0.0006567527,0.000314827],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005369411,"about_ca_system_score_gemma":0.0002279079,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008333502,"about_ca_topic_score_gemma":0.001803271,"domain_scores_codex":[0.9998266,0.0000268889,0.00001096662,0.00004969018,0.00005431334,0.00003158088],"domain_scores_gemma":[0.9999083,0.00002512663,0.00002362259,0.0000155319,0.00001382001,0.00001358885],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006223548,0.00001053472,0.00008678206,0.000043375,0.000004569656,0.00002378214,0.00001283836,0.0001291094,0.997463,0.000249525,0.00007337287,0.001840999],"study_design_scores_gemma":[0.00002582771,0.0002164222,0.0008928233,0.000006195159,0.00001064331,0.0001355789,0.00001536695,0.0009363644,0.9924392,0.0001988794,0.00511542,0.000007304806],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9194376,0.00911067,0.055482,0.001342385,0.0001545731,0.0002300847,0.001359577,0.0007145643,0.01216861],"genre_scores_gemma":[0.9588589,0.00321296,0.03271578,0.0003476476,0.00002626729,0.000122617,0.0004499443,0.00006987964,0.004196045],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001306756,"threshold_uncertainty_score":0.004371464,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01895999727692549,"score_gpt":0.2495113338521185,"score_spread":0.230551336575193,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}