{"id":"W2528150422","doi":"10.1371/journal.pgen.1006350","title":"Metal Chelation as a Powerful Strategy to Probe Cellular Circuitry Governing Fungal Drug Resistance and Morphogenesis","year":2016,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; Ministry of Trade, Industry and Energy; Canada Research Chairs","keywords":"Caspofungin; Echinocandin; Echinocandins; Biology; Candida albicans; Anidulafungin; Antifungal drug; Drug resistance; Ponatinib; Virulence; Allosteric regulation; Fungal protein; Microbiology; Mutant; Gene; Dasatinib; Cell biology; Signal transduction; Biochemistry; Tyrosine kinase; Enzyme; Amphotericin B","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002226416,0.0002038683,0.0003067596,0.00005770277,0.00008474988,0.00002705825,0.00009235273,0.0001058899,0.0001918273],"category_scores_gemma":[0.0002190722,0.0001550437,0.00007611827,0.0001668093,0.00009699115,0.00007329747,0.00005345823,0.0001109265,0.0002150817],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001113292,"about_ca_system_score_gemma":0.0001644296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005091204,"about_ca_topic_score_gemma":0.00008997173,"domain_scores_codex":[0.9983232,0.00005957034,0.0003121425,0.0004882672,0.0004833353,0.0003334985],"domain_scores_gemma":[0.9989688,0.00007974863,0.00008957904,0.0004231467,0.0001701773,0.0002685378],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002421998,0.0001025122,0.07562149,0.0001494552,0.00007210048,0.00004725752,0.0002219617,0.000001605643,0.921426,0.000174947,0.0003132949,0.001627192],"study_design_scores_gemma":[0.001175037,0.0003624832,0.1103997,0.0003589687,0.0003145068,0.00001480065,0.0003139444,0.00006345723,0.8823865,0.0006225826,0.003587764,0.0004002236],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904578,0.003073276,0.001307667,0.0006685516,0.00005203749,0.0005134942,0.00003189648,0.00005304483,0.003842229],"genre_scores_gemma":[0.9856992,0.0001722448,0.001030077,0.0001879754,0.0001313941,0.0000137767,0.000008452957,0.00003651963,0.01272031],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03903946,"threshold_uncertainty_score":0.6322498,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01895999727692549,"score_gpt":0.2495113338521185,"score_spread":0.230551336575193,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}