{"id":"W2528172799","doi":"10.1016/j.ejpb.2016.09.018","title":"Inhibition of carbonic anhydrase IX in glioblastoma multiforme","year":2016,"lang":"en","type":"article","venue":"European Journal of Pharmaceutics and Biopharmaceutics","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; Queen's University; McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Calgary","keywords":"Temozolomide; Glioblastoma; Cancer research; Acetazolamide; U87; Brain tumor; Glioma; Carbonic anhydrase; Downregulation and upregulation; Programmed cell death; Medicine; Chemistry; Enzyme; Pathology; Internal medicine; Biochemistry; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008819139,0.0001634916,0.0001832872,0.0001946353,0.00003405075,0.00001366963,0.0001032382,0.00005239427,0.00003530095],"category_scores_gemma":[0.00007358409,0.0001187202,0.0001015423,0.0001447381,0.000147127,0.0000211096,0.00008511784,0.0001676346,0.00000490402],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002434063,"about_ca_system_score_gemma":0.00004987744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":6.344862e-7,"about_ca_topic_score_gemma":0.00000256585,"domain_scores_codex":[0.9985937,0.0002244572,0.0006191408,0.0001660079,0.0001863046,0.0002103604],"domain_scores_gemma":[0.9991005,0.00002265829,0.0003934074,0.0001177464,0.0001970602,0.0001686324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005392014,0.0001262171,0.002349543,0.00003384348,0.00003611639,0.00006179686,0.00006628392,0.00002443798,0.9806896,0.00002227684,0.0003401138,0.01571061],"study_design_scores_gemma":[0.004369999,0.0007309727,0.0009277213,0.0001452905,0.00004728398,0.0001576269,0.00007133103,0.0001541586,0.9537719,0.00001423115,0.03944405,0.0001654508],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965238,0.001380631,0.0007368431,0.0003305151,0.000323683,0.00009314359,0.00002726621,0.000005062487,0.0005790865],"genre_scores_gemma":[0.9938052,0.005141389,0.000242617,0.0003805729,0.0002987974,5.52643e-7,0.000003294023,0.00002634823,0.0001012591],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03910394,"threshold_uncertainty_score":0.4841269,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02044720753991332,"score_gpt":0.282337964143052,"score_spread":0.2618907566031387,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}