{"id":"W2528228811","doi":"10.1056/nejmoa1611310","title":"Niraparib Maintenance Therapy in Platinum-Sensitive, Recurrent Ovarian Cancer","year":2016,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":2458,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; BC Cancer Agency; Princess Margaret Cancer Centre; University Health Network","funders":"Cilag; Genentech; PharmaMar; Medac; University College London; Clovis Oncology; Array BioPharma; USC Norris Comprehensive Cancer Center; Massachusetts Medical Society; Ohio State University; Teva Pharmaceutical Industries; Amgen; Pfizer; Myriad Genetics; AstraZeneca; Eli Lilly and Company; Mateon Therapeutics; GlaxoSmithKline","keywords":"Ovarian cancer; Platinum; Oncology; Maintenance therapy; Medicine; Internal medicine; Cancer; Chemotherapy; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001226194,0.0002800764,0.001320036,0.0002700051,0.0001778119,0.0003352792,0.0005054737,0.0003816911,0.000959799],"category_scores_gemma":[0.001336836,0.0001332258,0.0005713214,0.0003098637,0.0002977577,0.0002810267,0.000234727,0.0008519077,0.0001252274],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004111692,"about_ca_system_score_gemma":0.000494773,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002481768,"about_ca_topic_score_gemma":0.0005659609,"domain_scores_codex":[0.9995762,0.0002279217,0.0000488219,0.00005806237,0.00005878984,0.00003027486],"domain_scores_gemma":[0.9992014,0.0002609901,0.000281892,0.00005754106,0.000038742,0.0001594943],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.3591326,0.008435618,0.05186505,0.00367909,0.002623578,0.0009449045,0.0003755007,0.003536284,0.03577262,0.000361177,0.003875473,0.5293981],"study_design_scores_gemma":[0.3648377,0.4430687,0.1525459,0.0006911313,0.002539115,0.006483486,0.0001375874,0.004231271,0.01076069,0.001161702,0.01347829,0.00006453708],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.981375,0.01726104,0.000179284,0.0002431772,0.00005782209,0.0001768475,0.0001121862,0.00002274785,0.000571904],"genre_scores_gemma":[0.9941876,0.004495174,0.0003987018,0.0002450462,0.00008762192,0.0001774536,0.0002349843,0.000003645771,0.0001698595],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001320036,"threshold_uncertainty_score":0.006484747,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03768055663310116,"score_gpt":0.3259895611761575,"score_spread":0.2883090045430563,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}