{"id":"W2528236220","doi":"10.1038/nn.4398","title":"Novel genetic loci underlying human intracranial volume identified through genome-wide association","year":2016,"lang":"en","type":"article","venue":"Nature Neuroscience","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":261,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Neurological Institute and Hospital; SickKids Foundation; University of Toronto; University of Calgary; Trinity College; Douglas Mental Health University Institute; McGill University; Hospital for Sick Children","funders":"Scottish Mental Health Research Network; U.S. National Library of Medicine; National Institute of Biomedical Imaging and Bioengineering; National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Human Genome Research Institute; National Institute of Mental Health; National Institutes of Natural Sciences; Stichting voor de Technische Wetenschappen; Japan Society for the Promotion of Science; National Health and Medical Research Council; Australian Research Council; Biotechnology and Biological Sciences Research Council; Medical Research Council; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital; Heart And Stroke Foundation Of Quebec; University of California, San Diego; Genentech; Directorate for Biological Sciences; National Institutes of Health; Max Planck Instituut voor Psycholinguïstiek; National Institute on Aging; Universität Greifswald; Epilepsy Society; IXICO; Erasmus Medisch Centrum; University College London Hospitals NHS Foundation Trust; Mutuelle Générale de l'Education Nationale; Servier; Uppsala Universitet; University of New South Wales; Radboud Universitair Medisch Centrum; National Center for Research Resources; Genome Institute of Singapore; Universitair Medisch Centrum Groningen; Biomedical Research Council; Universitetet i Bergen; Max-Planck-Gesellschaft; Kuopion Yliopistollinen Sairaala; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Fondation pour la Recherche Médicale; Medizinische Universität Graz; National Institute for Health and Care Research; Austrian Science Fund; Vrije Universiteit Amsterdam; ZonMw; University of Melbourne; Centre for Cognitive Ageing and Cognitive Epidemiology; National Medical Research Council; Norges Forskningsråd; Stockholms Läns Landsting; National Heart, Lung, and Blood Institute; Universiteit Leiden; Institut National de la Santé et de la Recherche Médicale; Centre hospitalier régional universitaire de Lille; Northern California Institute for Research and Education; Agency for Science, Technology and Research; Canadian Institutes of Health Research; Knut och Alice Wallenbergs Stiftelse; European Commission; Parkinson's UK; Hersenstichting; U.S. Department of Defense; Commonwealth Scientific and Industrial Research Organisation; Broad Institute; Australian Government; Radboud Universiteit; Russian Foundation for Basic Research; Royal College of Surgeons in Ireland; Epilepsy Research UK; Scottish Funding Council; University College London; Massachusetts General Hospital; Harvard University; Translational Genomics Research Institute; Epilepsy Ireland; Texas Biomedical Research Institute; Svenska Forskningsrådet Formas; Karl-Franzens-Universität Graz; Mrs Gladys Row Fogo Charitable Trust; Centre d'Imagerie BioMédicale; Eisai; Sanofi; Leids Universitair Medisch Centrum; Foundation for the National Institutes of Health; National Alliance for Research on Schizophrenia and Depression; Hjartavernd; Bergens Forskningsstiftelse; Japan Agency for Medical Research and Development; Novartis Pharmaceuticals Corporation; Fundación Marqués de Valdecilla; Development of Innovative Strategies for a Transdisciplinary approach to ALZheimer's disease; Wellcome Trust; Agence Nationale de la Recherche; Johns Hopkins University; Pfizer; California NanoSystems Institute; Biogen; BioClinica; Science Foundation Ireland; Fondation Leducq; National Science Foundation; Vetenskapsrådet; Universiteit Utrecht; University of Minnesota; Science for Life Laboratory; Fondation de France; University of Toronto; Instituto de Salud Carlos III; Synarc; Lundbeckfonden; Accare; Age UK; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Brain Research Imaging Centre, University of Edinburgh; University of Southern California; GlaxoSmithKline; Heart and Stroke Foundation of Canada; Itä-Suomen Yliopisto; Koninklijke Nederlandse Akademie van Wetenschappen; Eli Lilly and Company; Autism Speaks; Bristol-Myers Squibb; Meso Scale Diagnostics; Université de Lille; Karolinska Institutet; U.S. Department of Energy; National University Health System; Alzheimer's Association; National Center for Advancing Translational Sciences; Bundesministerium für Bildung und Forschung; Ministry of Education, Culture, Sports, Science and Technology; Medpace","keywords":"Neuroscience; Genome-wide association study; Biology; Neuroscientist; Brain size; Association (psychology); Systems neuroscience; Genome; Human genome; Evolutionary biology; Genetics; Computational biology; Psychology; Gene; Single-nucleotide polymorphism; Medicine; Genotype; Central nervous system; Magnetic resonance imaging","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004040171,0.0001761563,0.000174021,0.0000421668,0.0003230944,0.0000508649,0.0004301559,0.0005038182,0.00004176276],"category_scores_gemma":[0.002082566,0.0001423103,0.0001011061,0.0002009565,0.0001202688,0.00001515192,0.0001502641,0.0002385884,0.00002951873],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009897866,"about_ca_system_score_gemma":0.00007426565,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002630446,"about_ca_topic_score_gemma":0.00005162972,"domain_scores_codex":[0.998132,0.000106714,0.000308456,0.0006641746,0.0002863998,0.0005022633],"domain_scores_gemma":[0.9990379,0.00008344951,0.0002715057,0.0003725597,0.000152474,0.00008211385],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000006252958,0.00004093158,0.1346497,0.000002448195,0.000009103952,0.000002572737,0.00002366593,0.00005061843,0.8613284,0.00008235606,0.003057255,0.0007467158],"study_design_scores_gemma":[0.0004617139,0.0001385213,0.9709687,0.000004438097,0.00001627665,0.00001247123,0.00001506268,0.00003508045,0.002774358,0.0005315549,0.02482673,0.0002150739],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9243655,0.0002389189,0.07142446,0.002190731,0.001000745,0.0001775193,0.00003173322,0.00002760519,0.0005428311],"genre_scores_gemma":[0.9887217,0.00009195619,0.001888453,0.003628778,0.0003046446,0.00001784697,0.00001803026,0.00002112785,0.005307512],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.858554,"threshold_uncertainty_score":0.5803244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02201716281641942,"score_gpt":0.2949872484371885,"score_spread":0.2729700856207691,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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