{"id":"W2528436478","doi":"10.1084/jem.20160635","title":"UNG protects B cells from AID-induced telomere loss","year":2016,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Miami Center for AIDS Research","keywords":"Telomere; Genome instability; Somatic hypermutation; Uracil-DNA glycosylase; Germinal center; DNA repair; B cell; Biology; Base excision repair; Cancer research; DNA damage; Activation-induced (cytidine) deaminase; Cell biology; Cell growth; DNA glycosylase; Antibody; Molecular biology; Gene; DNA; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000127882,0.0002321654,0.0001744232,0.0003363892,0.0001162254,0.0002222485,0.000186967,0.0002463108,0.0008861088],"category_scores_gemma":[0.0001542461,0.0001302368,0.0001220445,0.0001076798,0.000172274,0.0001021786,0.0002377048,0.0004193024,0.0002673637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001171362,"about_ca_system_score_gemma":0.0001553948,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002667432,"about_ca_topic_score_gemma":0.0002867116,"domain_scores_codex":[0.9999262,0.00001644651,0.00000632516,0.00001090988,0.00001560805,0.00002444104],"domain_scores_gemma":[0.9998382,0.00002560182,0.00004150338,0.00003368507,0.00001191095,0.00004902504],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002979629,0.00003669711,0.0004042047,0.00002733855,0.000007641639,0.00004495071,0.00001614902,0.00006288374,0.9961395,0.000121446,0.00003807165,0.002803257],"study_design_scores_gemma":[0.00005141021,0.001016212,0.007482011,0.00001372019,0.00002239954,0.0004349333,0.00002713249,0.0005152521,0.9865544,0.0002019769,0.003675917,0.000004696781],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960032,0.002139864,0.0007965373,0.00006732459,0.0000202205,0.000008100957,0.00008558687,0.0000830651,0.0007961848],"genre_scores_gemma":[0.9975142,0.0006737745,0.0005483697,0.00005117559,0.00001022525,0.000009103988,0.0001853555,0.00001018854,0.0009975398],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008861088,"threshold_uncertainty_score":0.002964318,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02890149451780868,"score_gpt":0.2972207136137833,"score_spread":0.2683192190959747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}