{"id":"W2528447563","doi":"10.7554/elife.18130","title":"The isolated voltage sensing domain of the Shaker potassium channel forms a voltage-gated cation channel","year":2016,"lang":"en","type":"article","venue":"eLife","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Shaker; Gating; Biophysics; Potassium channel; Ion channel; Chemistry; Allosteric regulation; Coupling (piping); Linker; KcsA potassium channel; Transmembrane domain; Membrane potential; Voltage-gated ion channel; Biochemistry; Materials science; Membrane; Biology; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001206159,0.0001766808,0.0002546393,0.0001022977,0.0001437777,0.0002807873,0.0002853481,0.0002217667,0.0005856382],"category_scores_gemma":[0.0001766233,0.00009627586,0.0001862082,0.0001173782,0.0003674137,0.0003278721,0.0003193171,0.0003822003,0.0003614931],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003317094,"about_ca_system_score_gemma":0.0002837169,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002416617,"about_ca_topic_score_gemma":0.0003104178,"domain_scores_codex":[0.9999013,0.00001215702,0.00000915302,0.0000329325,0.00002907365,0.00001531836],"domain_scores_gemma":[0.9998969,0.00001725078,0.00002994862,0.00001595978,0.0000130427,0.00002695992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008453229,0.000008683986,0.0003595522,0.00002622264,0.000006433432,0.00004103029,0.000009354378,0.0001260242,0.9978509,0.0002179672,0.0000177624,0.001251527],"study_design_scores_gemma":[0.00002633085,0.0001902065,0.007611004,0.000008026351,0.00002495519,0.0004995914,0.00004673559,0.002789524,0.9858926,0.0003695776,0.002532398,0.000009117122],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954044,0.0005756978,0.003294058,0.00004343397,0.00001808035,0.00000521956,0.00007201498,0.00004252594,0.0005446898],"genre_scores_gemma":[0.9960027,0.00024759,0.002345049,0.00002420217,0.000005793241,0.000007606782,0.0002826318,0.00001233731,0.001072065],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005856382,"threshold_uncertainty_score":0.002406776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008930167224271889,"score_gpt":0.2196903326598527,"score_spread":0.2107601654355808,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}