{"id":"W2528558988","doi":"10.1101/079806","title":"Alzheimer-related pathogenesis is dependent on neuronal receptor PTPσ","year":2016,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Pathogenesis; Genetically modified mouse; Amyloid precursor protein secretase; Neuroscience; Amyloid precursor protein; Neuroinflammation; Alzheimer's disease; Amyloid (mycology); BACE1-AS; Receptor; P3 peptide; Transgene; Cell biology; Biology; Chemistry; Disease; Medicine; Biochemistry; Internal medicine; Immunology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001589375,0.0001982834,0.0002263871,0.0001241663,0.0001050808,0.0004375982,0.0001166352,0.0001834302,0.001300098],"category_scores_gemma":[0.0001824504,0.00009638177,0.000193613,0.00008593007,0.000208687,0.0002010689,0.0002492016,0.0003135868,0.0005881988],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000171932,"about_ca_system_score_gemma":0.0001738426,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002779976,"about_ca_topic_score_gemma":0.0002678955,"domain_scores_codex":[0.9999058,0.00001013105,0.000007990534,0.00002487405,0.00003075094,0.0000204487],"domain_scores_gemma":[0.9999224,0.00001000528,0.00002918892,0.00001353444,0.00001069164,0.00001415909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001272885,0.00001436223,0.001156464,0.00004179997,0.00001049715,0.000238096,0.00001766185,0.00003638903,0.9948558,0.0004374097,0.00007568477,0.002988555],"study_design_scores_gemma":[0.00003560718,0.0003022947,0.03824444,0.00001759997,0.00003746817,0.003918845,0.00007702168,0.001031851,0.9499344,0.0009344005,0.00545704,0.000009034669],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860677,0.004367365,0.005387886,0.0002579483,0.00003958384,0.00001766816,0.0002428887,0.0001130737,0.003505866],"genre_scores_gemma":[0.996102,0.001201255,0.0007026102,0.00004457979,0.00001450408,0.000009294181,0.0001847832,0.000008248956,0.001732892],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001300098,"threshold_uncertainty_score":0.004349232,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02807148082184967,"score_gpt":0.2687126056491561,"score_spread":0.2406411248273064,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}