{"id":"W2528759573","doi":"10.20381/ruor-4859","title":"The combination of pan-ErbB tyrosine kinase inhibitor CI-1033 and lovastatin: A potential novel therapeutic approach in squamous cell carcinoma of the head and neck","year":2011,"lang":"en","type":"dissertation","venue":"Library and Archives Canada (Government of Canada)","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"ErbB; Head and neck; Tyrosine-kinase inhibitor; Cancer research; Tyrosine kinase; Head and neck squamous-cell carcinoma; Medicine; Basal cell; Lovastatin; Oncology; Internal medicine; Head and neck cancer; Cancer; Receptor; Surgery","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009820263,0.0002323157,0.0002545539,0.0003086957,0.0001920648,0.0002827354,0.0001821668,0.0002322117,0.002212783],"category_scores_gemma":[0.00003816078,0.00007939375,0.0002591674,0.0003026264,0.0001025077,0.000179553,0.0001067385,0.0004230237,0.000507329],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004797694,"about_ca_system_score_gemma":0.0006599193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001635125,"about_ca_topic_score_gemma":0.006692693,"domain_scores_codex":[0.9999667,0.000003809408,0.000002381896,0.000005259394,0.000008358934,0.00001344978],"domain_scores_gemma":[0.9999899,0.00000107691,0.00000189525,8.173369e-7,0.000002312747,0.000004042295],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001449769,0.0007616668,0.0005537313,0.0007189061,0.00004437023,0.000288885,0.00007049841,0.0003457298,0.8160205,0.0008512694,0.002179913,0.1767148],"study_design_scores_gemma":[0.0008741047,0.007761758,0.02129269,0.0001492285,0.0002816154,0.002025692,0.0001518035,0.0008207226,0.8487784,0.000448661,0.1173792,0.00003624394],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8306146,0.1385622,0.003797952,0.001746605,0.0004192762,0.0004508669,0.000782541,0.0002700426,0.02335579],"genre_scores_gemma":[0.9098514,0.06844469,0.004509771,0.0003275813,0.0001032409,0.0001178875,0.0007703438,0.00001881033,0.01585629],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002212783,"threshold_uncertainty_score":0.007402539,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008760140810670305,"score_gpt":0.1949173796245325,"score_spread":0.1861572388138622,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}