{"id":"W2528778266","doi":"10.3892/mmr.2016.5810","title":"Decreased expression of miR-9 due to E50K OPTN mutation causes disruption of the expression of BDNF leading to RGC-5 cell apoptosis","year":2016,"lang":"en","type":"article","venue":"Molecular Medicine Reports","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"","keywords":"Optineurin; Biology; Apoptosis; Neurotrophic factors; Gene silencing; Transfection; Cell biology; Transcription factor; Cell; Cell cycle; microRNA; Molecular biology; Cell culture; Genetics; Gene; Autophagy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001527919,0.0003862318,0.0002185663,0.0002629115,0.0001687066,0.0002357035,0.0001829263,0.0004113074,0.00126382],"category_scores_gemma":[0.0001452901,0.0001617234,0.0003992677,0.000130727,0.000346102,0.0001814915,0.0001972501,0.0005657276,0.0003806259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003200324,"about_ca_system_score_gemma":0.000215233,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000899533,"about_ca_topic_score_gemma":0.00124362,"domain_scores_codex":[0.9997631,0.00003855774,0.00004503479,0.00004764644,0.00006193005,0.00004371216],"domain_scores_gemma":[0.9998444,0.00003100931,0.00007287749,0.00001949457,0.000007827712,0.00002433902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004635992,0.00001859918,0.0001779208,0.00001694591,0.000004588078,0.0001089111,0.000006253023,0.00002941717,0.9992061,0.00005463221,0.0000150436,0.000315261],"study_design_scores_gemma":[0.00001024529,0.0002121302,0.006055259,0.000004301545,0.00001873552,0.0006330435,0.000029489,0.0006254827,0.991426,0.00003627302,0.000944195,0.00000477833],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969235,0.0005454951,0.001252011,0.00007487632,0.00003294937,0.00001460393,0.0002651218,0.00005758277,0.0008338384],"genre_scores_gemma":[0.9960437,0.0004163064,0.001775806,0.00006451611,0.000004252037,0.00002710528,0.0002864077,0.00001969675,0.00136218],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00126382,"threshold_uncertainty_score":0.004227936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008236160906806348,"score_gpt":0.2636641681522335,"score_spread":0.2554280072454271,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}