{"id":"W2529000802","doi":"10.1016/s0959-8049(16)31512-x","title":"2746 A Phase 2 open-label, multicenter study of single-agent rucaparib in the treatment of patients with relapsed ovarian cancer and a deleterious BRCA mutation","year":2015,"lang":"en","type":"article","venue":"European Journal of Cancer","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"BRCA mutation; Medicine; Ovarian cancer; Oncology; Internal medicine; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001369069,0.001680663,0.002483825,0.0004485881,0.0004471242,0.001044067,0.0008717597,0.001311547,0.005439765],"category_scores_gemma":[0.0009939342,0.0006701742,0.001689499,0.00043794,0.0009228891,0.000712125,0.0002633114,0.003518602,0.001515115],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006705684,"about_ca_system_score_gemma":0.001621182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0013026,"about_ca_topic_score_gemma":0.002719262,"domain_scores_codex":[0.9995452,0.0002427886,0.00001659755,0.0000758302,0.00003207902,0.00008760374],"domain_scores_gemma":[0.9993877,0.0001403699,0.00008304863,0.00005986375,0.00005083618,0.0002781374],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8503339,0.04036444,0.003374193,0.00070979,0.001645318,0.000262843,0.0001543652,0.003087965,0.02927908,0.0003436476,0.005734916,0.06470963],"study_design_scores_gemma":[0.7268918,0.2602269,0.004968192,0.00002479851,0.0004342574,0.0002645124,0.0000435759,0.001821857,0.002770243,0.0001599731,0.002354085,0.00003970632],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987583,0.002635492,0.001052188,0.0006789406,0.0002510974,0.002893733,0.00238052,0.0002336851,0.002291253],"genre_scores_gemma":[0.9804828,0.002747795,0.002868411,0.001161039,0.0003172852,0.002324053,0.005017492,0.00009749785,0.004983494],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005439765,"threshold_uncertainty_score":0.01819777,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08533086144846243,"score_gpt":0.3659178891722676,"score_spread":0.2805870277238052,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}