{"id":"W2529117670","doi":"10.1016/j.devcel.2016.09.002","title":"Adaptation to Stressors by Systemic Protein Amyloidogenesis","year":2016,"lang":"en","type":"article","venue":"Developmental Cell","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":175,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"National Institute of General Medical Sciences; National Cancer Institute; Canadian Institutes of Health Research; Sylvester Comprehensive Cancer Center, University of Miami Health Systems","keywords":"Biology; Cell biology; Chaperone (clinical); Amyloid (mycology); P3 peptide; Amyloid disease; Amyloid precursor protein; Alzheimer's disease; Disease; Amyloid β; Amyloid fibril","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009479874,0.0000970148,0.00006699962,0.00003345138,0.00005724756,0.00001500276,0.0001345406,0.00005628233,0.00003672192],"category_scores_gemma":[0.0000258487,0.00007152106,0.00002510833,0.00006285407,0.00001512855,0.000003463892,0.00007784581,0.00002035332,0.0001978324],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005282569,"about_ca_system_score_gemma":0.00007587052,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003797877,"about_ca_topic_score_gemma":0.00002439769,"domain_scores_codex":[0.9992105,0.00003089384,0.0001283002,0.0002452954,0.0001491277,0.000235908],"domain_scores_gemma":[0.9996983,0.000004643956,0.00002763484,0.000103431,0.00003640003,0.000129625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004733762,0.00001703773,0.0007468366,0.00001381161,0.000008594876,0.000001499727,0.00003487159,0.00000241055,0.9857216,0.000002006281,0.003349066,0.01005487],"study_design_scores_gemma":[0.0003166608,0.00008863462,0.000433246,0.00003496232,0.000001132337,0.000004845945,0.0001851952,0.000003400037,0.9863595,0.00000166621,0.01243676,0.000134019],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996597,0.0001799356,0.002051999,0.0001051055,0.00002651275,0.0002907391,0.00002617681,0.00001056532,0.0007119852],"genre_scores_gemma":[0.9752457,0.00003682246,0.001590671,0.00009095763,0.0000299595,0.00008195343,0.00004319425,0.00001630164,0.02286442],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02215243,"threshold_uncertainty_score":0.2916544,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01016751242532265,"score_gpt":0.2209646273196755,"score_spread":0.2107971148943529,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}