{"id":"W2529117670","doi":"10.1016/j.devcel.2016.09.002","title":"Adaptation to Stressors by Systemic Protein Amyloidogenesis","year":2016,"lang":"en","type":"article","venue":"Developmental Cell","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":175,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"National Institute of General Medical Sciences; National Cancer Institute; Canadian Institutes of Health Research; Sylvester Comprehensive Cancer Center, University of Miami Health Systems","keywords":"Biology; Cell biology; Chaperone (clinical); Amyloid (mycology); P3 peptide; Amyloid disease; Amyloid precursor protein; Alzheimer's disease; Disease; Amyloid β; Amyloid fibril","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002436321,0.0006290804,0.0005111414,0.000203654,0.0001950276,0.0005435114,0.0002612638,0.0004335782,0.001354913],"category_scores_gemma":[0.0002419865,0.0001888531,0.0004176136,0.0001114942,0.0003644509,0.0004901367,0.0006731568,0.001004996,0.0004223164],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000266549,"about_ca_system_score_gemma":0.0002218035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002297909,"about_ca_topic_score_gemma":0.0003799559,"domain_scores_codex":[0.9997391,0.00004720622,0.0000225893,0.00007767611,0.00005408907,0.00005922003],"domain_scores_gemma":[0.9995518,0.00003301734,0.00009823597,0.0001273061,0.00005500148,0.00013455],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001460866,0.00001897496,0.0008349239,0.00001230906,0.00000923862,0.0001311973,0.00001495111,0.00007141058,0.997403,0.0001097501,0.00005700149,0.001191147],"study_design_scores_gemma":[0.00003279246,0.0006938975,0.09334974,0.00001963839,0.00005670193,0.002409262,0.0003802038,0.003219537,0.8937497,0.002240044,0.003813633,0.00003480478],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910731,0.0008424405,0.005749741,0.0002840497,0.00007092031,0.00001997522,0.0002506758,0.0002373315,0.001471759],"genre_scores_gemma":[0.9956613,0.0004144764,0.001775243,0.0001472713,0.00003073365,0.00002272349,0.0002567632,0.00007137866,0.001620071],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001354913,"threshold_uncertainty_score":0.004532576,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01016751242532265,"score_gpt":0.2209646273196755,"score_spread":0.2107971148943529,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}