{"id":"W2529252494","doi":"10.1007/s00221-016-4789-z","title":"The neuronal metabolite NAA regulates histone H3 methylation in oligodendrocytes and myelin lipid composition","year":2016,"lang":"en","type":"article","venue":"Experimental Brain Research","topic":"Neurogenesis and neuroplasticity mechanisms","field":"Neuroscience","cited_by":52,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; SCIEX; Kent State University; University of Akron; National Multiple Sclerosis Society","keywords":"Oligodendrocyte; Sphingomyelin; Myelin; Chemistry; Histone; Histone acetyltransferase; H3K4me3; Biochemistry; Molecular biology; Cell biology; Biology; Gene expression; Endocrinology; Central nervous system; Gene; Cholesterol; Promoter","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001643984,0.0002071644,0.0002140448,0.0002280674,0.0004173587,0.000710007,0.0003098944,0.0003332965,0.001460167],"category_scores_gemma":[0.0002235935,0.0001920057,0.0002767863,0.0001799516,0.0005318309,0.0006942899,0.0004238599,0.0004027673,0.0003644445],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009557155,"about_ca_system_score_gemma":0.0005295734,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004937346,"about_ca_topic_score_gemma":0.008973869,"domain_scores_codex":[0.9998811,0.00002110937,0.00000839471,0.00003737465,0.00001835715,0.00003364805],"domain_scores_gemma":[0.9998834,0.00001319178,0.0000257813,0.00001447102,0.00002996559,0.00003321491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007073388,0.00001303509,0.001238689,0.00002281689,0.00001803371,0.0000413442,0.00005170505,0.00003065907,0.9952391,0.0005547201,0.00004430824,0.002038152],"study_design_scores_gemma":[0.00001717708,0.0001049154,0.01854197,0.000006707654,0.00002712223,0.0001198771,0.0002421582,0.0004510042,0.9781335,0.0006056482,0.001737971,0.00001196512],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900388,0.003754319,0.003446698,0.0003159349,0.0000701307,0.000009317806,0.0003470923,0.00005368157,0.001964042],"genre_scores_gemma":[0.9946238,0.0009533805,0.001364031,0.00005592261,0.000008144614,0.000008139956,0.0002166883,0.00002756278,0.00274224],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004937346,"threshold_uncertainty_score":0.009817243,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07414227135533681,"score_gpt":0.3833961096996842,"score_spread":0.3092538383443474,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}