{"id":"W2529324599","doi":"10.1038/ncomms12853","title":"Interference-driven spacer acquisition is dominant over naive and primed adaptation in a native CRISPR–Cas system","year":2016,"lang":"en","type":"article","venue":"Nature Communications","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":152,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Marsden Fund; Royal Society Te Apārangi; Royal Society; University of Toronto; University of Otago","keywords":"CRISPR; Biology; Plasmid; DNA; Computational biology; Genetics; Cas9; Acquired immune system; Trans-activating crRNA; Nucleic acid; Gene; Immune system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009705361,0.000100841,0.00009645818,0.00006892206,0.00006003569,0.00001367942,0.0001992008,0.0002040669,0.000005549928],"category_scores_gemma":[0.00006308957,0.00007891391,0.00003166391,0.00008536646,0.00006333244,0.000007636497,0.0001966599,0.0001574093,0.000003060344],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005479649,"about_ca_system_score_gemma":0.00003209999,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002474888,"about_ca_topic_score_gemma":0.0004612913,"domain_scores_codex":[0.9994212,0.00006532442,0.0001408683,0.0001861582,0.0000649303,0.0001215372],"domain_scores_gemma":[0.9992053,0.00004943652,0.00005483592,0.0005533352,0.00009714204,0.0000399606],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001080126,0.00008359014,0.008497693,0.00004302415,0.00008469989,0.000001682628,0.002712387,0.0000372442,0.9768008,0.004054503,0.001694121,0.005882244],"study_design_scores_gemma":[0.003373681,0.000361944,0.1731685,0.000830171,0.00008601761,0.00004796707,0.003217604,0.009252517,0.7829333,0.00021202,0.02575608,0.0007601753],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9249676,0.01053774,0.05870456,0.003092797,0.0002227291,0.0006292515,0.0001038089,0.00003479786,0.001706725],"genre_scores_gemma":[0.9965279,0.0008964424,0.002250857,0.00009519138,0.00003488517,0.00005100656,0.00004047895,0.00001161639,0.00009161342],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1938675,"threshold_uncertainty_score":0.3218016,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01151100367186522,"score_gpt":0.319327210018697,"score_spread":0.3078162063468318,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}