{"id":"W2529324599","doi":"10.1038/ncomms12853","title":"Interference-driven spacer acquisition is dominant over naive and primed adaptation in a native CRISPR–Cas system","year":2016,"lang":"en","type":"article","venue":"Nature Communications","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":152,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Marsden Fund; Royal Society Te Apārangi; Royal Society; University of Toronto; University of Otago","keywords":"CRISPR; Biology; Plasmid; DNA; Computational biology; Genetics; Cas9; Acquired immune system; Trans-activating crRNA; Nucleic acid; Gene; Immune system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002407459,0.0001922966,0.0002832864,0.000171511,0.0001225384,0.0003990562,0.0002004409,0.0002124617,0.0006326064],"category_scores_gemma":[0.0003476129,0.0001742179,0.0001894739,0.0001409304,0.0001845689,0.0002554371,0.0002485645,0.0004326934,0.0002240461],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003068255,"about_ca_system_score_gemma":0.0002028457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002817051,"about_ca_topic_score_gemma":0.0005861955,"domain_scores_codex":[0.9997204,0.00002338425,0.00002294771,0.00008067002,0.0001066847,0.00004585629],"domain_scores_gemma":[0.9995858,0.0001130134,0.0001145245,0.00006956531,0.00003524033,0.00008186445],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003058975,0.00001056756,0.0004442935,0.000007629467,0.000002116789,0.00001863155,0.000005609362,0.00005263202,0.9987444,0.00003368668,0.000006593906,0.0006432183],"study_design_scores_gemma":[0.000009019987,0.0002482788,0.01822538,0.000002447181,0.000009756922,0.0003112017,0.00001798143,0.002767752,0.9777916,0.00009843867,0.0005104891,0.000007700973],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941583,0.0001323765,0.004913872,0.00001618452,0.000007143855,0.00001033733,0.00008972514,0.00009117167,0.0005809994],"genre_scores_gemma":[0.9947256,0.00009338104,0.004136869,0.00002619482,0.000003566644,0.00001379943,0.000178122,0.00002431401,0.0007980409],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006326064,"threshold_uncertainty_score":0.002226233,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01151100367186522,"score_gpt":0.319327210018697,"score_spread":0.3078162063468318,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}