{"id":"W2529391496","doi":"10.1021/acs.molpharmaceut.6b00781","title":"Biomimetic ApoE-Reconstituted High Density Lipoprotein Nanocarrier for Blood–Brain Barrier Penetration and Amyloid Beta-Targeting Drug Delivery","year":2016,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"Shanghai Jiao Tong University; Science and Technology Commission of Shanghai Municipality; Shanghai Education Development Foundation; Shanghai Municipal Education Commission; National Natural Science Foundation of China","keywords":"Nanocarriers; Blood–brain barrier; Apolipoprotein E; Chemistry; Drug delivery; In vivo; Drug delivery to the brain; Liposome; Amyloid beta; Biophysics; Pharmacology; Biodistribution; Cell biology; In vitro; Biochemistry; Medicine; Biology; Neuroscience; Central nervous system; Pathology; Peptide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001673748,0.0002172246,0.0001581374,0.0001108192,0.00008465994,0.0001427118,0.0001225551,0.0003259009,0.0002618416],"category_scores_gemma":[0.0001382766,0.0000844627,0.0002086918,0.00006845791,0.0001303583,0.0002180428,0.000132812,0.0002761958,0.0001212722],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002420269,"about_ca_system_score_gemma":0.0001409836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004701586,"about_ca_topic_score_gemma":0.0004898821,"domain_scores_codex":[0.9999263,0.00001286836,0.000007649109,0.00001745077,0.00002082304,0.00001481593],"domain_scores_gemma":[0.9999502,0.000008912049,0.00001747964,0.000005207765,0.00001081183,0.000007354758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002437533,0.00001280004,0.00003398192,0.00002337241,0.000002714765,0.00002774172,0.000006317515,0.00006490096,0.9986292,0.0000853614,0.00001797152,0.001071312],"study_design_scores_gemma":[0.000007598182,0.0001166341,0.0003070233,0.000002160518,0.000007924403,0.0001064529,0.000004355411,0.001196271,0.9972096,0.0000224112,0.001015809,0.000003762478],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9682103,0.003642828,0.0264938,0.0001880624,0.00007337191,0.0000677838,0.00009570177,0.0001353426,0.001092752],"genre_scores_gemma":[0.9835092,0.001090107,0.01383156,0.0000620037,0.00001129574,0.0000441879,0.00007415778,0.00001234607,0.001365119],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004701586,"threshold_uncertainty_score":0.001756012,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02223477215487179,"score_gpt":0.3046888458133216,"score_spread":0.2824540736584498,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}