{"id":"W2529391496","doi":"10.1021/acs.molpharmaceut.6b00781","title":"Biomimetic ApoE-Reconstituted High Density Lipoprotein Nanocarrier for Blood–Brain Barrier Penetration and Amyloid Beta-Targeting Drug Delivery","year":2016,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"Shanghai Jiao Tong University; Science and Technology Commission of Shanghai Municipality; Shanghai Education Development Foundation; Shanghai Municipal Education Commission; National Natural Science Foundation of China","keywords":"Nanocarriers; Blood–brain barrier; Apolipoprotein E; Chemistry; Drug delivery; In vivo; Drug delivery to the brain; Liposome; Amyloid beta; Biophysics; Pharmacology; Biodistribution; Cell biology; In vitro; Biochemistry; Medicine; Biology; Neuroscience; Central nervous system; Pathology; Peptide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003740523,0.0002757248,0.0003125373,0.0001438399,0.0002180493,0.00004541999,0.0000872354,0.0001043887,0.0001362021],"category_scores_gemma":[0.0001890018,0.0002084311,0.0001536582,0.000150578,0.0002205151,0.0001378869,0.00007487583,0.0001287911,0.00003141129],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000808745,"about_ca_system_score_gemma":0.0002810138,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008227408,"about_ca_topic_score_gemma":0.00001127874,"domain_scores_codex":[0.9982158,0.0001332883,0.0002959897,0.0004258139,0.0003719711,0.0005571172],"domain_scores_gemma":[0.9985633,0.0001491513,0.00008914105,0.0002753237,0.0002557091,0.0006673415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008075736,0.0003646982,0.007309525,0.0002003927,0.006076189,0.000469972,0.00008484897,0.000002083781,0.9516527,0.0002076632,0.0009095919,0.03191474],"study_design_scores_gemma":[0.007500746,0.0001866267,0.0009686464,0.0001035809,0.001903323,0.00004951158,0.00002756864,0.0003312423,0.9862833,0.0003347845,0.002040472,0.0002701746],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870957,0.007182959,0.001974776,0.001812611,0.0001136772,0.001490026,0.0001764355,0.00007610921,0.00007771409],"genre_scores_gemma":[0.9955408,0.0003084957,0.002810226,0.0007534758,0.0001075365,0.0001764641,0.0001381724,0.00004900935,0.0001158152],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0346306,"threshold_uncertainty_score":0.8499573,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02223477215487179,"score_gpt":0.3046888458133216,"score_spread":0.2824540736584498,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}