{"id":"W2529744408","doi":"10.1016/j.biomaterials.2016.09.032","title":"Endosomal pH modulation by peptide-gold nanoparticle hybrids enables potent anti-inflammatory activity in phagocytic immune cells","year":2016,"lang":"en","type":"article","venue":"Biomaterials","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":73,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; University of British Columbia; Child and Family Research Institute; University of Toronto; BC Children's Hospital","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Cystic Fibrosis Canada; Child and Family Research Institute; Crohn's and Colitis Foundation of Canada; Michael Smith Health Research BC","keywords":"Inflammation; Immune system; Innate immune system; Endosome; In vivo; Receptor; Signal transduction; Cell biology; Materials science; Immunology; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002089652,0.0002945407,0.0002234558,0.0001138993,0.0001252624,0.0003727791,0.0001688314,0.0004791917,0.0007727157],"category_scores_gemma":[0.0001830589,0.0001430817,0.0001679603,0.00008171686,0.0001931601,0.0003069516,0.0003030569,0.000339057,0.0002582245],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002223121,"about_ca_system_score_gemma":0.0001103481,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001121127,"about_ca_topic_score_gemma":0.0002392571,"domain_scores_codex":[0.999832,0.00003096543,0.00001005321,0.00003966889,0.00003500321,0.00005220513],"domain_scores_gemma":[0.9999238,0.0000250265,0.0000177231,0.000008855432,0.00001094851,0.00001355538],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004744486,0.000007965635,0.00002538274,0.0000164974,0.000002380674,0.00002620146,0.000008142303,0.00004183075,0.9991199,0.00007355239,0.00001556003,0.0006151203],"study_design_scores_gemma":[0.000005299171,0.00008562908,0.0002885737,0.000001769276,0.000004460018,0.00006258678,0.000007413558,0.0003149335,0.9987063,0.00001763188,0.0005029495,0.000002360179],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937413,0.001130032,0.003318063,0.00008266531,0.0000288741,0.00001671487,0.00004129839,0.00005132013,0.001589644],"genre_scores_gemma":[0.9969517,0.000302038,0.001455039,0.00005617466,0.000008865959,0.00001280941,0.00003587229,0.00001111449,0.001166392],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007727157,"threshold_uncertainty_score":0.002584994,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008242195816294408,"score_gpt":0.2102147266330726,"score_spread":0.2019725308167782,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}