{"id":"W2529745594","doi":"10.1016/j.ijpddr.2016.09.005","title":"Profiling the macrofilaricidal effects of flubendazole on adult female Brugia malayi using RNAseq","year":2016,"lang":"en","type":"article","venue":"International Journal for Parasitology Drugs and Drug Resistance","topic":"Parasitic Diseases Research and Treatment","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; McGill University; Fonds Québécois de la Recherche sur la Nature et les Technologies; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Brugia malayi; Biology; Ivermectin; Pharmacology; Onchocerciasis; Anthelmintic; Transcriptome; Lymphatic filariasis; Drug; Filariasis; Immunology; Gene expression; Gene; Helminths; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001885497,0.0001467818,0.0002493678,0.000122113,0.0001793915,0.00003132394,0.0001825201,0.00004891684,0.0000177221],"category_scores_gemma":[0.0003626416,0.00007826662,0.0001601327,0.00005508108,0.0002071613,0.00008188738,0.00003221447,0.0001353431,0.000006095939],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001244588,"about_ca_system_score_gemma":0.0001639249,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001013423,"about_ca_topic_score_gemma":0.000008164608,"domain_scores_codex":[0.9986845,0.00007796483,0.0003004871,0.0002131342,0.000434884,0.00028902],"domain_scores_gemma":[0.9983147,0.0007248581,0.000187108,0.0001480876,0.0004497094,0.0001755684],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.03287926,0.002391223,0.7244627,0.0009467914,0.004987393,0.003132839,0.001261457,0.00005271228,0.1221049,0.06016957,0.007460466,0.04015065],"study_design_scores_gemma":[0.04037474,0.001672434,0.282156,0.006174318,0.001122687,0.002851777,0.001310224,0.001022788,0.6398606,0.01351028,0.00904686,0.0008973283],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912239,0.00132526,0.001440266,0.004269081,0.0006110062,0.0003926007,0.00007320999,0.000009955091,0.0006547255],"genre_scores_gemma":[0.9961949,0.0003666873,0.001173884,0.0003019033,0.0002538165,0.00003265856,0.000007069645,0.00001485941,0.001654218],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5177557,"threshold_uncertainty_score":0.319162,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01171126567940686,"score_gpt":0.3630537210245856,"score_spread":0.3513424553451788,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}