{"id":"W2529803615","doi":"10.1016/j.coph.2016.08.004","title":"Modulators of HBV capsid assembly as an approach to treating hepatitis B virus infection","year":2016,"lang":"en","type":"review","venue":"Current Opinion in Pharmacology","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":false,"ca_institutions":"Arbutus Biopharma (Canada)","funders":"","keywords":"Capsid; Virology; Hepatitis B virus; Virus; Polymerase; Biology; Hepatitis B; Interferon; Chronic hepatitis; Medicine; DNA; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004509992,0.0005842945,0.002481592,0.001014351,0.00008121601,0.00000980073,0.0002013718,0.0003714229,0.0001901819],"category_scores_gemma":[0.0002266752,0.0004719121,0.0003564273,0.0006917128,0.0001174302,0.0001361905,0.0002019078,0.00060487,0.0001872815],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000701974,"about_ca_system_score_gemma":0.0005397357,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002880113,"about_ca_topic_score_gemma":0.0001097901,"domain_scores_codex":[0.99634,0.0006642637,0.001308933,0.0008078651,0.0003385204,0.0005404205],"domain_scores_gemma":[0.9983371,0.0002245894,0.0005965643,0.0003543042,0.000192384,0.000294986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003876422,0.0009782432,0.01109548,0.02395765,0.0002883945,0.000003748768,0.000269045,0.000004971746,0.00005711875,0.0001636541,0.006191697,0.9569513],"study_design_scores_gemma":[0.001123794,0.0005582332,0.002031247,0.01531473,0.000524401,0.0000654711,0.000003211367,0.00007168665,0.000076998,0.0000220481,0.9797468,0.000461439],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005313158,0.9786678,0.0002152601,0.0000296573,0.01152797,0.002711778,0.0001709607,0.0001005346,0.00126288],"genre_scores_gemma":[0.001334258,0.9951558,0.0001485253,0.00003478641,0.001646881,0.001253887,0.0002837036,0.00009060505,0.00005151766],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.973555,"threshold_uncertainty_score":0.9997733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1327080849331835,"score_gpt":0.4689897982430735,"score_spread":0.3362817133098901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}