{"id":"W2529971671","doi":"10.1097/mib.0000000000000949","title":"The Gut Microbiome of Pediatric Crohnʼs Disease Patients Differs from Healthy Controls in Genes That Can Influence the Balance Between a Healthy and Dysregulated Immune Response","year":2016,"lang":"en","type":"article","venue":"Inflammatory Bowel Diseases","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Izaak Walton Killam Health Centre; Dalhousie University","funders":"Canadian Institutes of Health Research","keywords":"Microbiome; Metagenomics; Immune system; KEGG; Biology; Disease; Immunity; Immunology; Innate immune system; Feces; Dysbiosis; Gut flora; Bioinformatics; Medicine; Gene; Genetics; Internal medicine; Microbiology; Gene expression; Gene ontology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002433447,0.0002962193,0.0003536978,0.0006805258,0.0003085927,0.0004602816,0.0001121951,0.0003198049,0.001671994],"category_scores_gemma":[0.0009480412,0.0001249952,0.0003289707,0.0007097955,0.0002276629,0.0002843989,0.0003583822,0.000255076,0.0001439803],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002977216,"about_ca_system_score_gemma":0.0002061811,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009050264,"about_ca_topic_score_gemma":0.001319642,"domain_scores_codex":[0.9997494,0.00004098191,0.00002703737,0.00008658967,0.00004090237,0.0000551797],"domain_scores_gemma":[0.9995351,0.0001025792,0.0002479861,0.00002113969,0.00002543058,0.00006786774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001085482,0.00006574915,0.9582626,0.0001324458,0.0001216835,0.000555426,0.0002419384,0.0001387777,0.02788551,0.00008789,0.0001686051,0.01125386],"study_design_scores_gemma":[0.00001247501,0.0001727435,0.9963278,0.00002364085,0.00006345528,0.001291223,0.0002906734,0.0001594093,0.001057038,0.0001093434,0.0004877131,0.000004544523],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998754,0.0005239517,0.0001299429,0.00004045997,0.000003679328,0.000004594087,0.0003305742,0.000005212872,0.0002074661],"genre_scores_gemma":[0.9986464,0.0002898384,0.0004648516,0.00003451436,0.00000379882,0.00001013353,0.0004682106,0.000003699767,0.00007847829],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001671994,"threshold_uncertainty_score":0.005593419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005852122549124879,"score_gpt":0.2291540332011076,"score_spread":0.2233019106519827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}