{"id":"W2530096957","doi":"10.1038/ncomms12795","title":"KCNE1 induces fenestration in the Kv7.1/KCNE1 channel complex that allows for highly specific pharmacological targeting","year":2016,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Janssen Pharmaceuticals; National Heart, Lung, and Blood Institute; Deutsche Forschungsgemeinschaft","keywords":"Adamantane; Ion channel; Small molecule; Mutagenesis; Potassium channel; Chemistry; Gating; Protein subunit; Biology; Electrophysiology; Cell biology; Biophysics; Computational biology; Biochemistry; Mutation; Receptor; Neuroscience","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002346357,0.0002238426,0.0002961089,0.00008586323,0.0001919936,0.0002900964,0.0003597889,0.0002844488,0.001504322],"category_scores_gemma":[0.0002503478,0.0001646608,0.000205985,0.00008213177,0.0003250095,0.0001953155,0.000242319,0.0005998356,0.000426143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004075984,"about_ca_system_score_gemma":0.0001975452,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006198073,"about_ca_topic_score_gemma":0.0009030092,"domain_scores_codex":[0.9998281,0.00003456189,0.00001899689,0.00004076606,0.00004599609,0.00003155476],"domain_scores_gemma":[0.9997671,0.00006474364,0.00007159315,0.00004438572,0.00001927743,0.00003286378],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000100225,0.00001694223,0.0001162054,0.00002124063,0.000005081065,0.00006773106,0.0000234402,0.000115684,0.9985386,0.0002003984,0.00003885341,0.0007554895],"study_design_scores_gemma":[0.00001677849,0.00008589392,0.001363901,0.000003550222,0.000004853161,0.0003003868,0.00001604507,0.0004967602,0.9962199,0.00005090056,0.001436405,0.000004608279],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964478,0.0004175233,0.001966966,0.00006772235,0.00001362301,0.00001662895,0.0001340357,0.00004375428,0.0008919088],"genre_scores_gemma":[0.9964901,0.0002663329,0.001746926,0.00004994235,0.00000419359,0.00001585578,0.0002470672,0.00003209328,0.001147461],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001504322,"threshold_uncertainty_score":0.00503248,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07880598253699803,"score_gpt":0.3526359328357987,"score_spread":0.2738299502988008,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}