{"id":"W2530185749","doi":"10.1016/j.devcel.2016.09.015","title":"Comparative Principles of DNA Methylation Reprogramming during Human and Mouse In Vitro Primordial Germ Cell Specification","year":2016,"lang":"en","type":"article","venue":"Developmental Cell","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":116,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Gates Cambridge Trust; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Medical Research Council; Wellcome; Health Sciences Centre Foundation; Wellcome Trust","keywords":"Biology; Reprogramming; DNA methylation; Germ cell; Methylation; Cell biology; In vitro; DNA; Germ; Genetics; Cell; Gene; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002843514,0.0001377178,0.0001175173,0.0002711226,0.0001167842,0.0003281704,0.0001614118,0.0001398844,0.000702656],"category_scores_gemma":[0.0002136611,0.0001907843,0.0001760248,0.0001104774,0.0001947188,0.0001629745,0.0001694014,0.0002753224,0.0002389088],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000218322,"about_ca_system_score_gemma":0.0001757731,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00063006,"about_ca_topic_score_gemma":0.0009672131,"domain_scores_codex":[0.9998599,0.00002822061,0.00001516286,0.0000373843,0.00003841716,0.00002091128],"domain_scores_gemma":[0.9998888,0.00003137345,0.0000280619,0.00002725702,0.00001075356,0.00001383693],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005944265,0.000005968432,0.0006407918,0.00002151054,0.000006568087,0.00002462989,0.0000280145,0.0001368161,0.9959416,0.0004699019,0.00001470028,0.002650097],"study_design_scores_gemma":[0.000005675308,0.0001391986,0.01201685,0.000005718648,0.00001703914,0.0002891778,0.00002428749,0.0005567598,0.9841314,0.0002355968,0.002573047,0.000005433943],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9637183,0.003491799,0.02564669,0.00006149388,0.00002997704,0.00007755991,0.0008243047,0.0002565253,0.005893271],"genre_scores_gemma":[0.989027,0.001343131,0.007480654,0.00004035156,0.000006169815,0.00005789964,0.0005502924,0.00004577034,0.001448681],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000702656,"threshold_uncertainty_score":0.002350569,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03191191949393014,"score_gpt":0.2758382097662123,"score_spread":0.2439262902722821,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}