{"id":"W2530311943","doi":"10.1159/000449224","title":"Pharmacogenetic Analysis of Functional Glutamate System Gene Variants and Clinical Response to Clozapine","year":2016,"lang":"en","type":"article","venue":"Complex Psychiatry","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Addiction and Mental Health; University of Toronto; Ontario Institute for Cancer Research","funders":"National Institute of Environmental Health Sciences; International Business Machines Corporation","keywords":"Pharmacogenetics; Clozapine; Glutamate receptor; Pharmacology; Medicine; Gene; Schizophrenia (object-oriented programming); Genetics; Biology; Genotype; Psychiatry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003988778,0.0003257376,0.0003248175,0.0006531902,0.0002175566,0.0003279659,0.0002409172,0.0003749218,0.001794081],"category_scores_gemma":[0.00171654,0.0001391449,0.0004568306,0.0008199266,0.0002697383,0.0001088861,0.0001977566,0.0002327274,0.0002376854],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002538769,"about_ca_system_score_gemma":0.0001887566,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005199081,"about_ca_topic_score_gemma":0.004153296,"domain_scores_codex":[0.9995347,0.0001650329,0.00006111127,0.0001262653,0.00006738795,0.00004544658],"domain_scores_gemma":[0.9992229,0.0002335378,0.0003434702,0.00006370057,0.00004885364,0.00008768397],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003909265,0.0001000953,0.9690479,0.00002419864,0.0003307807,0.0009717388,0.0001792419,0.0005041038,0.018834,0.00009221699,0.000185682,0.005820774],"study_design_scores_gemma":[0.00007225106,0.0002862516,0.9971723,0.000005015409,0.0000780035,0.0006195827,0.00005493228,0.0007287049,0.00076104,0.00005579196,0.0001589655,0.000007309099],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993537,0.00005384706,0.0001012733,0.00001838514,0.000001862491,0.000009702296,0.0002158103,0.000004090929,0.0002412448],"genre_scores_gemma":[0.9995978,0.00001817984,0.0001140386,0.00001813376,0.000002206674,0.000006596476,0.0001468826,0.000002860234,0.00009318767],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005199081,"threshold_uncertainty_score":0.01033765,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1256926095567472,"score_gpt":0.4077666525266602,"score_spread":0.282074042969913,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}