{"id":"W2530414747","doi":"10.1128/aac.01959-16","title":"Beauvericin Potentiates Azole Activity via Inhibition of Multidrug Efflux, Blocks Candida albicans Morphogenesis, and Is Effluxed via Yor1 and Circuitry Controlled by Zcf29","year":2016,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; University of Toronto; Concordia University","keywords":"Efflux; Candida albicans; Itraconazole; Azole; Beauvericin; Microbiology; Schizosaccharomyces pombe; Pharmacology; Fungi imperfecti; Morphogenesis; Chemistry; Multiple drug resistance; Biology; Biochemistry; Antibiotics; Yeast; Antifungal; Mycotoxin; Saccharomyces cerevisiae","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000968149,0.0002540515,0.0002282919,0.0001752127,0.0001322623,0.0003042317,0.0001929661,0.0002067522,0.001034283],"category_scores_gemma":[0.00007920463,0.000107495,0.0002587879,0.0001072791,0.000215302,0.000169249,0.0001630738,0.0006337497,0.0002370169],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002364167,"about_ca_system_score_gemma":0.0001716511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005815662,"about_ca_topic_score_gemma":0.00096785,"domain_scores_codex":[0.9998894,0.00001622806,0.000008820537,0.00002696833,0.00003379342,0.0000247476],"domain_scores_gemma":[0.999916,0.00001237484,0.0000312099,0.00001101584,0.000008468061,0.00002090615],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005442468,0.00000942666,0.00008591732,0.00001463431,0.000001767668,0.00002295852,0.000003489405,0.00004463917,0.9991215,0.00003950876,0.00001758083,0.0005841965],"study_design_scores_gemma":[0.00001286898,0.0001937447,0.005931496,0.000004739608,0.00001033858,0.0001697715,0.0000190057,0.0005471008,0.9912493,0.00003294455,0.001824826,0.000003854568],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910622,0.00267381,0.002961191,0.0002043087,0.00003049245,0.00002557794,0.0005472173,0.0001384153,0.002356902],"genre_scores_gemma":[0.994752,0.0009246327,0.001524911,0.0001201267,0.000008148633,0.00001429778,0.0005146405,0.00002043768,0.002120765],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001034283,"threshold_uncertainty_score":0.00346005,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00593971814591731,"score_gpt":0.2288094213504027,"score_spread":0.2228697032044854,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}