{"id":"W2530476023","doi":"10.1002/aic.15544","title":"Reaction engineering with enzymes: A relatively uncharted territory","year":2016,"lang":"en","type":"article","venue":"AIChE Journal","topic":"Enzyme Catalysis and Immobilization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Toronto; National Science Foundation","keywords":"Candida antarctica; Transesterification; Chemical reaction engineering; Kinetics; Chemistry; Work (physics); Lipase; Acrylate; Chemical kinetics; Organic chemistry; Thermodynamics; Enzyme; Catalysis; Chemical engineering; Polymer; Copolymer; Engineering; Physics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001464356,0.00008364962,0.00006913675,0.00004245416,0.0000529255,0.00001584816,0.00006247542,0.00007085946,0.00001840905],"category_scores_gemma":[0.00007075758,0.00004965368,0.00004295007,0.00005108076,0.00001932065,0.00001447364,0.00001415559,0.00007657414,0.000008684297],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002719362,"about_ca_system_score_gemma":0.00004317004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001627507,"about_ca_topic_score_gemma":0.00000486808,"domain_scores_codex":[0.9995088,0.00002453369,0.0001280108,0.0001241259,0.00009473074,0.0001197861],"domain_scores_gemma":[0.9996359,0.000008696004,0.00008790456,0.0001208507,0.00008602624,0.00006056584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003747042,0.00001574919,0.001226856,0.000002078706,0.00005427054,0.000002541428,0.00002691614,0.00002462067,0.9952593,0.0000298314,0.002195226,0.001125101],"study_design_scores_gemma":[0.0008648483,0.0003985116,0.01155426,0.0000839499,0.00003569626,0.0002840575,0.00005824091,0.0000388729,0.8776329,0.00001435928,0.1088587,0.0001756238],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9608054,0.0005574768,0.03775189,0.0002930033,0.0001549078,0.00005489101,0.000003045019,0.00001346904,0.0003659519],"genre_scores_gemma":[0.9974962,0.0001894099,0.0004582183,0.00005861164,0.0003990517,0.000004045919,0.00001383768,0.00001666843,0.001363988],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1176264,"threshold_uncertainty_score":0.2024819,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005701118956991871,"score_gpt":0.1999389747466026,"score_spread":0.1942378557896107,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}