{"id":"W2530492696","doi":"10.1164/rccm.201509-1818oc","title":"Acute Respiratory Distress Syndrome Neutrophils Have a Distinct Phenotype and Are Resistant to Phosphoinositide 3-Kinase Inhibition","year":2016,"lang":"en","type":"article","venue":"American Journal of Respiratory and Critical Care Medicine","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":153,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"NIHR Cambridge Biomedical Research Centre; British Lung Foundation; National Institute for Health and Care Research; Wellcome Trust","keywords":"Medicine; Phosphoinositide 3-kinase; Bronchoalveolar lavage; Immunology; Respiratory burst; PI3K/AKT/mTOR pathway; Signal transduction; Cell biology; Biology; Internal medicine; Lung","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002188804,0.0002741348,0.0002791726,0.0002084551,0.0001487895,0.0003880472,0.0001210728,0.0002323308,0.001071751],"category_scores_gemma":[0.000363303,0.0001003992,0.0001659463,0.0001751714,0.000186068,0.0001299408,0.0002160192,0.000288694,0.0002951873],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001443777,"about_ca_system_score_gemma":0.00009789549,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001737183,"about_ca_topic_score_gemma":0.0002507778,"domain_scores_codex":[0.999701,0.00005263865,0.00004185655,0.00006003651,0.00009410443,0.0000503453],"domain_scores_gemma":[0.9998102,0.0000301385,0.00007705557,0.00001965514,0.00002927733,0.00003360352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006252762,0.00005225304,0.02153461,0.00008115507,0.00002205964,0.0002935123,0.00007755971,0.000120768,0.9691296,0.00006889375,0.00007326236,0.007921123],"study_design_scores_gemma":[0.00006864198,0.002720155,0.4660746,0.00003686903,0.00008013351,0.005762273,0.0003695099,0.001181413,0.5198733,0.0002441064,0.003570713,0.0000183342],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970542,0.0008360457,0.001223639,0.00005240944,0.000006001186,0.00003364834,0.00024655,0.00002603231,0.0005215047],"genre_scores_gemma":[0.9976738,0.0003959727,0.0008584189,0.000073084,0.000006976634,0.00005374931,0.0005816363,0.000004991371,0.0003513717],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001071751,"threshold_uncertainty_score":0.003585339,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01359989136643279,"score_gpt":0.2710713814249524,"score_spread":0.2574714900585195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}