{"id":"W2530498311","doi":"10.1021/acs.biochem.6b00951","title":"DNA Repair by DNA: The UV1C DNAzyme Catalyzes Photoreactivation of Cyclobutane Thymine Dimers in DNA More Effectively than Their de Novo Formation","year":2016,"lang":"en","type":"article","venue":"Biochemistry","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Photolyase; Pyrimidine dimer; Thymine; Deoxyribozyme; DNA; Cyclobutane; Oligonucleotide; Stereochemistry; Chemistry; DNA repair; Guanine; Cytosine; Biology; Nucleotide; Biochemistry; Photochemistry; Gene; Ring (chemistry)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003751355,0.0005546816,0.0003401085,0.0002222262,0.0001875348,0.0005647197,0.0004513763,0.000783238,0.001298531],"category_scores_gemma":[0.0005138994,0.000216438,0.0001890576,0.0002034448,0.000366747,0.0004279179,0.0002279211,0.000725059,0.0006325741],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004692278,"about_ca_system_score_gemma":0.000286437,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000254053,"about_ca_topic_score_gemma":0.0003355308,"domain_scores_codex":[0.999635,0.00004989028,0.00001934999,0.0001583255,0.00009708142,0.00004037992],"domain_scores_gemma":[0.9997424,0.00007169258,0.00006266993,0.00004040857,0.00004013428,0.00004260806],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002368167,0.00001082506,0.00009412046,0.00006471624,0.000004070615,0.00001588424,0.00001286931,0.00004377451,0.9980184,0.0001153007,0.00002022819,0.001576199],"study_design_scores_gemma":[0.000002870233,0.00003744416,0.0002419144,0.000002496266,0.000001973757,0.00008876689,0.00000315819,0.0001683616,0.9986987,0.00001964089,0.0007325263,0.0000021005],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9654673,0.004024067,0.02677474,0.0001810044,0.00006398227,0.00009794054,0.000262869,0.0003103362,0.002817827],"genre_scores_gemma":[0.9761516,0.001054931,0.01845614,0.00008695196,0.00001693827,0.00006697554,0.000482263,0.00006021412,0.003623909],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001298531,"threshold_uncertainty_score":0.004343987,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004556835182575512,"score_gpt":0.2310714573772747,"score_spread":0.2265146221946992,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}