{"id":"W2530498639","doi":"10.1002/bdd.2046","title":"Identification of non‐reported bupropion metabolites in human plasma","year":2016,"lang":"en","type":"article","venue":"Biopharmaceutics & Drug Disposition","topic":"Poisoning and overdose treatments","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Hamilton Health Sciences Foundation","keywords":"Bupropion; Pharmacokinetics; Pharmacology; Glucuronidation; Active metabolite; Metabolite; Chemistry; Biopharmaceutics; Hydroxylation; Drug; Medicine; Smoking cessation; Microsome; Biological activity; Biochemistry; Pharmacognosy; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002108144,0.0001318108,0.0002180384,0.0002006147,0.0000476104,0.000009172129,0.00005319956,0.00006373734,0.00002800169],"category_scores_gemma":[0.00003058592,0.00009400944,0.00007520313,0.0002191758,0.00005949589,0.0001318772,0.00001871005,0.00006657077,0.00002625188],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001285307,"about_ca_system_score_gemma":0.00003448034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004050981,"about_ca_topic_score_gemma":0.000004243468,"domain_scores_codex":[0.9988372,0.00004235276,0.0004775079,0.0002300921,0.000233129,0.0001797637],"domain_scores_gemma":[0.9993442,0.00003059314,0.0002242296,0.00022378,0.00009433601,0.00008287474],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001723145,0.0004054081,0.0518775,0.00006342697,0.00006531324,0.00002235704,0.0001789501,0.000002130017,0.9404259,0.0001435771,0.0000425131,0.006600587],"study_design_scores_gemma":[0.002541,0.00004135837,0.2411407,0.0002264673,0.000221321,0.00001287428,0.00002786751,0.0004990221,0.7550063,0.00006451437,0.000136167,0.00008237822],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984412,0.0002038732,0.0001801948,0.0003591342,0.0001560272,0.0003516979,0.00004100809,0.00004571804,0.0002211872],"genre_scores_gemma":[0.9987214,0.0001794916,0.00009598992,0.00003951929,0.00005648376,0.00002766844,0.00009303035,0.00001783787,0.0007686397],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1892632,"threshold_uncertainty_score":0.3833594,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02198132284144714,"score_gpt":0.3417027279132424,"score_spread":0.3197214050717953,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}