{"id":"W2530584373","doi":"10.1182/blood.v108.11.2214.2214","title":"Noggin Overexpression Enhances Leukemic Progenitors Self-Renewal in AML by Abrogating the BMP Pathway Activation.","year":2006,"lang":"en","type":"article","venue":"Blood","topic":"Bone and Joint Diseases","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"Noggin; Bone morphogenetic protein; Progenitor cell; Haematopoiesis; CD34; Bone morphogenetic protein 7; Biology; Bone morphogenetic protein 2; Stem cell; Bone marrow; Cell biology; Internal medicine; Cancer research; Molecular biology; Endocrinology; Immunology; Medicine; Genetics; Gene; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001111796,0.0001892727,0.0001845199,0.0001871259,0.00007153816,0.0002357592,0.0000928199,0.00009804478,0.000992442],"category_scores_gemma":[0.0001070763,0.0000752935,0.0001372424,0.0001154685,0.0001582894,0.00008122609,0.0001649957,0.0002236216,0.000231572],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001752571,"about_ca_system_score_gemma":0.000119163,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000520929,"about_ca_topic_score_gemma":0.000587152,"domain_scores_codex":[0.9999175,0.00001550639,0.000008167202,0.00001118012,0.00002667521,0.00002089074],"domain_scores_gemma":[0.9999495,0.00001164148,0.00001245302,0.000005444275,0.000003137004,0.00001792834],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001384801,0.00001676191,0.0003869384,0.00002182623,0.000002931241,0.00003191939,0.00001292783,0.00004467745,0.9983544,0.00004520572,0.00002095134,0.0009228707],"study_design_scores_gemma":[0.00002220218,0.0004050535,0.008991018,0.000004656724,0.00002265963,0.0003030582,0.00003861335,0.0006403681,0.9866776,0.00003265754,0.002859914,0.000002166445],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998301,0.000481334,0.0004247663,0.00001689472,0.000006184629,0.00001063794,0.0001371568,0.00002524523,0.0005968626],"genre_scores_gemma":[0.9978018,0.0002808486,0.0004530497,0.00001050448,0.000003116702,0.00001329456,0.0003424103,0.000008025566,0.00108688],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000992442,"threshold_uncertainty_score":0.003320038,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005547645318219449,"score_gpt":0.2239977724730307,"score_spread":0.2184501271548112,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}