{"id":"W2530594373","doi":"10.1182/blood.v112.11.202.202","title":"An Upstream Insulator Element Regulates DLK1 Imprinting in AML","year":2008,"lang":"en","type":"article","venue":"Blood","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre","funders":"","keywords":"Biology; Genomic imprinting; MEG3; CpG site; DNA methylation; Methylation; Imprinting (psychology); Molecular biology; Promoter; Genetics; Cancer research; Gene; Uniparental disomy; Gene expression; Downregulation and upregulation; Long non-coding RNA; Chromosome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005117394,0.0001008585,0.0001020043,0.0002213814,0.0000766822,0.0001137926,0.00008288259,0.00007916521,0.002086541],"category_scores_gemma":[0.0001220656,0.00007551101,0.0001132131,0.0001254889,0.0001317962,0.00004438207,0.0001580326,0.0001626395,0.0002925486],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000188553,"about_ca_system_score_gemma":0.00007643479,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003850499,"about_ca_topic_score_gemma":0.0007070899,"domain_scores_codex":[0.9999357,0.000008578351,0.00000494663,0.00001722255,0.00001849485,0.00001512725],"domain_scores_gemma":[0.9999251,0.0000190243,0.00002848058,0.000006223783,0.000004731749,0.00001631344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002281834,0.0000137819,0.009334642,0.00001971899,0.000007009612,0.0001145849,0.00002112154,0.00007186274,0.9871494,0.0001065262,0.00006836472,0.002864801],"study_design_scores_gemma":[0.00006952152,0.0003521827,0.3904613,0.00001530761,0.00006704482,0.001705397,0.00008837713,0.002679041,0.598623,0.000401902,0.005525033,0.0000117449],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982168,0.0002586083,0.000608527,0.0000348659,0.000006034271,0.000004695038,0.0003305272,0.00004320166,0.0004966677],"genre_scores_gemma":[0.9989955,0.00005798594,0.0002771866,0.00001930224,0.000002597203,0.000002374496,0.0002485185,0.000006547077,0.0003899645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002086541,"threshold_uncertainty_score":0.006980181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008113948638552441,"score_gpt":0.2259848819923523,"score_spread":0.2178709333537999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}