{"id":"W2530594373","doi":"10.1182/blood.v112.11.202.202","title":"An Upstream Insulator Element Regulates DLK1 Imprinting in AML","year":2008,"lang":"en","type":"article","venue":"Blood","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre","funders":"","keywords":"Biology; Genomic imprinting; MEG3; CpG site; DNA methylation; Methylation; Imprinting (psychology); Molecular biology; Promoter; Genetics; Cancer research; Gene; Uniparental disomy; Gene expression; Downregulation and upregulation; Long non-coding RNA; Chromosome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001295313,0.0001305093,0.0001224274,0.00004368772,0.00006888067,0.00001397226,0.0001702988,0.00009421903,0.00002281013],"category_scores_gemma":[0.00003174244,0.0001304503,0.00005337821,0.00007871985,0.00003477311,0.000003206685,0.0001010922,0.00006302336,0.000008842793],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005333059,"about_ca_system_score_gemma":0.00004009491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005820128,"about_ca_topic_score_gemma":0.00002013201,"domain_scores_codex":[0.9990217,0.00003128501,0.0002329421,0.0003278999,0.00009430665,0.0002918363],"domain_scores_gemma":[0.9994547,0.000003611621,0.00006284226,0.00037173,0.00003125889,0.00007586459],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000002368981,0.000241326,0.3546631,0.000006805813,0.00002093561,0.000006148831,0.0000792509,0.00004578727,0.6428556,0.00001319456,0.00001740583,0.002048025],"study_design_scores_gemma":[0.001001463,0.0002277754,0.4257063,0.00001056637,0.000009100022,0.0001151868,0.00008244731,0.00006794536,0.5714699,0.00002587162,0.001116901,0.0001665326],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989206,0.0002703206,0.00005703557,0.00002541703,0.00005396534,0.0001176636,0.000002357062,0.00001472279,0.0005379628],"genre_scores_gemma":[0.9971552,0.000100948,0.002365069,0.00005801187,0.000141054,0.00001298309,0.00002604424,0.00002167105,0.0001190401],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07138577,"threshold_uncertainty_score":0.5319611,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008113948638552441,"score_gpt":0.2259848819923523,"score_spread":0.2178709333537999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}