{"id":"W2530661236","doi":"10.1182/blood.v120.21.576.576","title":"BP-2-047, a Novel Small-Molecule Inhibitor of Stat3 Is Active in Myeloma Pre-Clinical Models: Rationale for Treatment of Stat3-Dependent Multiple Myeloma","year":2012,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre","funders":"","keywords":"Multiple myeloma; Cancer research; STAT3; Angiogenesis; Biology; In vivo; Cell culture; Phosphorylation; Immunology; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002319448,0.0004237621,0.0003151174,0.0002784419,0.0001395779,0.0002344718,0.0003545639,0.0002690727,0.001510948],"category_scores_gemma":[0.0000744356,0.0001455444,0.0002605362,0.0002034299,0.0002539474,0.0001658299,0.0001201446,0.00101897,0.0004362431],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002992988,"about_ca_system_score_gemma":0.000389845,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005414617,"about_ca_topic_score_gemma":0.001384208,"domain_scores_codex":[0.9999151,0.00001640134,0.000005609413,0.00001007382,0.00003019207,0.0000226524],"domain_scores_gemma":[0.9999553,0.000006104514,0.000009588091,0.000003807218,0.000006815483,0.00001840131],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009809689,0.0007794466,0.0002678998,0.0001454965,0.00001961817,0.00008028145,0.00001466226,0.000363815,0.9863157,0.000323801,0.0002983586,0.01040999],"study_design_scores_gemma":[0.0007118002,0.01242521,0.003656195,0.0000182035,0.00008100809,0.0004330837,0.00001926507,0.0018814,0.9728252,0.000102289,0.007833432,0.00001285488],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9804655,0.006925197,0.005239404,0.0004824573,0.0001255475,0.0006348011,0.001043202,0.0003110272,0.004772946],"genre_scores_gemma":[0.9847633,0.004144828,0.004985162,0.0001630156,0.00004104046,0.0003269079,0.001566032,0.00002389832,0.003985711],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001510948,"threshold_uncertainty_score":0.005054653,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1055143992602165,"score_gpt":0.3619929512069461,"score_spread":0.2564785519467297,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}