{"id":"W2530784802","doi":"10.1530/jme-16-0024","title":"Antiestrogens: structure-activity relationships and use in breast cancer treatment","year":2016,"lang":"en","type":"review","venue":"Journal of Molecular Endocrinology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University; Université de Montréal; McGill University; Institute for Research in Immunology and Cancer","funders":"Canadian Institutes of Health Research; Université de Montréal; Canadian Imperial Bank of Commerce","keywords":"Fulvestrant; Tamoxifen; Raloxifene; Estrogen receptor; Downregulation and upregulation; Selective estrogen receptor modulator; Estrogen receptor alpha; Chemistry; Breast cancer; Antiestrogen; Estrogen; Cancer research; Agonist; Receptor; Pharmacology; Partial agonist; Internal medicine; Cancer; Endocrinology; Medicine; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005211398,0.0007292982,0.00118299,0.00219087,0.0002506593,0.0007124273,0.0008874692,0.0009204106,0.0046652],"category_scores_gemma":[0.000693744,0.0003075577,0.0004539577,0.00207634,0.0003911688,0.000851261,0.0005816371,0.001733815,0.002513554],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005242642,"about_ca_system_score_gemma":0.0005619989,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009076621,"about_ca_topic_score_gemma":0.001991354,"domain_scores_codex":[0.999805,0.00003046058,0.00002866101,0.00003183832,0.00008562294,0.00001845119],"domain_scores_gemma":[0.9997279,0.0001194276,0.00004225716,0.000009593802,0.00007577134,0.00002493586],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001003145,0.00009845507,0.00019649,0.008722162,0.0000815766,0.0001592268,0.00003549358,0.0003340766,0.001562746,0.002565968,0.0197815,0.9663619],"study_design_scores_gemma":[0.00002591861,0.0001193421,0.0007732833,0.001773814,0.0001026707,0.001087205,0.0000303125,0.00008197679,0.0005369498,0.00127054,0.9941838,0.00001402001],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001789669,0.998354,0.0001055427,0.0001708152,0.0001208165,0.000006379371,0.00002680498,0.000008806942,0.001027893],"genre_scores_gemma":[0.001012175,0.9978241,0.0001602275,0.0001469672,0.0001123494,0.000006353345,0.00004316049,0.000001570856,0.0006931587],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0046652,"threshold_uncertainty_score":0.01560664,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0270901418319448,"score_gpt":0.3076354254905174,"score_spread":0.2805452836585726,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}