{"id":"W2530814035","doi":"10.1182/blood-2016-04-708560","title":"Spectrum of somatic mutation dynamics in chronic myeloid leukemia following tyrosine kinase inhibitor therapy","year":2016,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":139,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto","funders":"","keywords":"Mutation; Myeloid leukemia; Tyrosine-kinase inhibitor; Tyrosine kinase; Cancer research; Medicine; Persistence (discontinuity); Somatic cell; Biology; Immunology; Oncology; Internal medicine; Genetics; Receptor; Cancer; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003303164,0.000118469,0.0002273783,0.0008777158,0.0002148107,0.0003796172,0.0001510116,0.000182821,0.0004405093],"category_scores_gemma":[0.001022255,0.0000897881,0.0001212975,0.000514748,0.0002760905,0.000217106,0.0003693402,0.000146607,0.0001051984],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002817315,"about_ca_system_score_gemma":0.0001354732,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000958673,"about_ca_topic_score_gemma":0.001592341,"domain_scores_codex":[0.9997755,0.00003865576,0.00002098361,0.00005115623,0.00007395886,0.00003969386],"domain_scores_gemma":[0.9996008,0.0001043385,0.0001471723,0.00003283613,0.00006710021,0.00004776622],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007178853,0.00005575144,0.7290121,0.00006823256,0.00008384317,0.0006837845,0.0006224806,0.001695877,0.2259851,0.000306668,0.0002359425,0.04053235],"study_design_scores_gemma":[0.00001061253,0.0002021934,0.97068,0.00000974116,0.00003082536,0.002084489,0.000273185,0.005150478,0.02030845,0.0004007814,0.0008330078,0.00001611981],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999006,0.0001977411,0.0004333392,0.00001175408,7.001854e-7,0.000005975154,0.00007615126,0.000009131891,0.0002592739],"genre_scores_gemma":[0.9993469,0.00007359485,0.0003605756,0.000007651862,0.000001108253,0.00000506615,0.0001230626,0.000003076476,0.00007901715],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000958673,"threshold_uncertainty_score":0.002044141,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009926625770245863,"score_gpt":0.2481338579790809,"score_spread":0.2382072322088351,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}