{"id":"W2530888279","doi":"10.1182/blood.v126.23.638.638","title":"Crispr-Cas9 Saturating Mutagenesis Reveals an Achilles Heel in the BCL11A Erythroid Enhancer for Fetal Hemoglobin Induction (by Genome Editing)","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"","keywords":"Enhancer; CRISPR; Biology; Cas9; Genetics; Genome editing; Enhancer RNAs; Context (archaeology); Gene; Guide RNA; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002019258,0.000322741,0.0003015964,0.0001811529,0.0001544162,0.0003283419,0.0003942744,0.000407072,0.00205391],"category_scores_gemma":[0.000154827,0.0002449142,0.0003065545,0.0001033563,0.0002458859,0.0001196908,0.0003682319,0.0006896287,0.0007258612],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002829552,"about_ca_system_score_gemma":0.0002058062,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004873068,"about_ca_topic_score_gemma":0.001036329,"domain_scores_codex":[0.9997953,0.00002491173,0.00002038082,0.00005736742,0.00006402393,0.00003811798],"domain_scores_gemma":[0.9998828,0.00002905653,0.00003863842,0.00001764723,0.000008896656,0.00002296103],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002568015,0.00001169018,0.00006699722,0.00002149667,0.00000353776,0.00005591884,0.000009443309,0.0001337464,0.9980941,0.0001750126,0.00003441189,0.001367835],"study_design_scores_gemma":[0.00001656847,0.0001082849,0.001049186,0.000008287757,0.00001332643,0.0002720003,0.00001277551,0.003046113,0.9910813,0.00009449902,0.004288828,0.000008796898],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.902804,0.0004936097,0.09014097,0.0001817028,0.00008365909,0.0001683767,0.0008268747,0.001312893,0.00398809],"genre_scores_gemma":[0.9645885,0.0001620192,0.03000404,0.0000871,0.000006340719,0.00006217916,0.0005515591,0.0001241876,0.004414049],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00205391,"threshold_uncertainty_score":0.006871045,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02362297927072579,"score_gpt":0.2805470926701266,"score_spread":0.2569241133994008,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}