{"id":"W2530902519","doi":"10.1182/blood.v126.23.2799.2799","title":"Safety and Efficacy of Ruxolitinib in an 1869-Patient Cohort of JUMP: An Open-Label, Multicenter, Single-Arm, Expanded-Access Study in Patients with Myelofibrosis","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; St. Paul's Hospital; University Health Network; University of British Columbia","funders":"","keywords":"Medicine; Ruxolitinib; Myelofibrosis; Internal medicine; Tolerability; Clinical endpoint; Phases of clinical research; Median follow-up; Surgery; International Prognostic Scoring System; Clinical trial; Adverse effect; Chemotherapy; Bone marrow; Myelodysplastic syndromes","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001267022,0.0006414882,0.0009310578,0.0002681326,0.0003823006,0.0008136081,0.000372545,0.0005942576,0.001763117],"category_scores_gemma":[0.0008992972,0.0002922776,0.0007715803,0.0002981352,0.0004790542,0.0006990859,0.0004927306,0.0009139202,0.000569935],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004177428,"about_ca_system_score_gemma":0.000462154,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005960012,"about_ca_topic_score_gemma":0.0008465758,"domain_scores_codex":[0.999595,0.0001581442,0.00002405745,0.00009604423,0.00006201028,0.0000647827],"domain_scores_gemma":[0.999065,0.0001096934,0.0002442037,0.0001061399,0.00007880426,0.000396223],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.3709178,0.01925057,0.5426177,0.0003200646,0.001865083,0.001040926,0.0005052439,0.001451852,0.02520139,0.0002115215,0.00368956,0.03292833],"study_design_scores_gemma":[0.07607125,0.09457672,0.8176865,0.00003402768,0.001353226,0.00138576,0.000242342,0.002951934,0.002442574,0.0001651165,0.003013918,0.00007666858],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991598,0.0001165668,0.00004849957,0.00004004755,0.000006003121,0.00005811784,0.0003537929,0.000007286054,0.0002099148],"genre_scores_gemma":[0.9970375,0.00008969892,0.0001566285,0.0001458142,0.00005835401,0.00007695108,0.002046219,0.000004509857,0.0003842934],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001763117,"threshold_uncertainty_score":0.006700695,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05333994591219693,"score_gpt":0.3292649248419586,"score_spread":0.2759249789297617,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}